Microtubule-targeting agents (MTAs) such as paclitaxel and the vinca alkaloids are among
the most important medical weapons available to combat cancer. MTAs interfere with …

Microtubule-targeting agents (MTAs) constitute a diverse group of chemical compounds that
bind to microtubules and affect their properties and function. Disruption of microtubules …

Tubulin plays essential roles in vital cellular activities and is the target of a wide range of
proteins and ligands. Here, using a combined computational and crystallographic fragment …

Plants are an important source of chemically diverse natural products that target
microtubules, one of the most successful targets in cancer therapy. Colchicine, paclitaxel …

The 2018 marine pharmacology literature review represents a continuation of the previous
11 reviews of a series initiated in 1998. Preclinical marine pharmacology research during …

Microtubules (MTs) are hollow cylinders made of tubulin, a GTPase responsible for essential
functions during cell growth and division, and thus, key target for anti-tumor drugs. In MTs …

Tubulin, the microtubules and their dynamic behavior are amongst the most successful
antitumor, antifungal, antiparasitic, and herbicidal drug targets. Sulfonamides are exemplary …

Microtubules are cytoskeletal polymers of tubulin and composed of α-and β-tubulin
heterodimers, which are regarded as one of the most important, promising and successful …

It has been proposed that one of the mechanisms of taxane-site ligand-mediated tubulin
activation is modulation of the structure of a switch element (the M-loop) from a disordered …

Targeting microtubules is the most effective wide-spectrum pharmacological strategy in
antitumoral chemotherapy, and current research focuses on reducing main drawbacks …