Microtubule-targeting agents: strategies to hijack the cytoskeleton
MO Steinmetz, AE Prota - Trends in cell biology, 2018 - cell.com
Microtubule-targeting agents (MTAs) such as paclitaxel and the vinca alkaloids are among
the most important medical weapons available to combat cancer. MTAs interfere with …
the most important medical weapons available to combat cancer. MTAs interfere with …
[HTML][HTML] Microtubule-targeting agents and their impact on cancer treatment
V Čermák, V Dostál, M Jelínek, L Libusová… - European journal of cell …, 2020 - Elsevier
Microtubule-targeting agents (MTAs) constitute a diverse group of chemical compounds that
bind to microtubules and affect their properties and function. Disruption of microtubules …
bind to microtubules and affect their properties and function. Disruption of microtubules …
Comprehensive analysis of binding sites in tubulin
T Mühlethaler, D Gioia, AE Prota… - Angewandte …, 2021 - Wiley Online Library
Tubulin plays essential roles in vital cellular activities and is the target of a wide range of
proteins and ligands. Here, using a combined computational and crystallographic fragment …
proteins and ligands. Here, using a combined computational and crystallographic fragment …
Beyond the paclitaxel and vinca alkaloids: Next generation of plant-derived microtubule-targeting agents with potential anticancer activity
D Zhang, A Kanakkanthara - Cancers, 2020 - mdpi.com
Plants are an important source of chemically diverse natural products that target
microtubules, one of the most successful targets in cancer therapy. Colchicine, paclitaxel …
microtubules, one of the most successful targets in cancer therapy. Colchicine, paclitaxel …
Marine pharmacology in 2018: Marine compounds with antibacterial, antidiabetic, antifungal, anti-inflammatory, antiprotozoal, antituberculosis and antiviral activities; …
AMS Mayer, ML Pierce, K Howe, AD Rodríguez… - Pharmacological …, 2022 - Elsevier
The 2018 marine pharmacology literature review represents a continuation of the previous
11 reviews of a series initiated in 1998. Preclinical marine pharmacology research during …
11 reviews of a series initiated in 1998. Preclinical marine pharmacology research during …
Structural model for differential cap maturation at growing microtubule ends
Microtubules (MTs) are hollow cylinders made of tubulin, a GTPase responsible for essential
functions during cell growth and division, and thus, key target for anti-tumor drugs. In MTs …
functions during cell growth and division, and thus, key target for anti-tumor drugs. In MTs …
Antitubulin sulfonamides: The successful combination of an established drug class and a multifaceted target
A Vicente‐Blázquez, M González… - Medicinal research …, 2019 - Wiley Online Library
Tubulin, the microtubules and their dynamic behavior are amongst the most successful
antitumor, antifungal, antiparasitic, and herbicidal drug targets. Sulfonamides are exemplary …
antitumor, antifungal, antiparasitic, and herbicidal drug targets. Sulfonamides are exemplary …
An overview of tubulin modulators deposited in protein data bank
H Guo, X Li, Y Guo, L Zhen - Medicinal Chemistry Research, 2019 - Springer
Microtubules are cytoskeletal polymers of tubulin and composed of α-and β-tubulin
heterodimers, which are regarded as one of the most important, promising and successful …
heterodimers, which are regarded as one of the most important, promising and successful …
Crystal structure of the cyclostreptin-tubulin adduct: Implications for tubulin activation by taxane-site ligands
FA Balaguer, T Mühlethaler, J Estévez-Gallego… - International journal of …, 2019 - mdpi.com
It has been proposed that one of the mechanisms of taxane-site ligand-mediated tubulin
activation is modulation of the structure of a switch element (the M-loop) from a disordered …
activation is modulation of the structure of a switch element (the M-loop) from a disordered …
PM534, an Optimized Target-Protein Interaction Strategy through the Colchicine Site of Tubulin
D Lucena-Agell, MJ Guillén, R Matesanz… - Journal of Medicinal …, 2024 - ACS Publications
Targeting microtubules is the most effective wide-spectrum pharmacological strategy in
antitumoral chemotherapy, and current research focuses on reducing main drawbacks …
antitumoral chemotherapy, and current research focuses on reducing main drawbacks …