Voltage-gated sodium (Nav) channels are intrinsic plasma membrane proteins that initiate
the action potential in electrically excitable cells. They are a major focus of research in …

We present evidence that regulation of dense-core secretory granule biogenesis and
hormone secretion in endocrine cells is dependent on chromogranin A (CGA) …

The voltage-sensitive sodium channel confers electrical excitability on neurons, a
fundamental property required for higher processes including cognition. The ion-conducting …

Proinsulin is packaged into nascent (immature, clathrin-coated) secretory granules in the
trans-Golgi network (TGN) of the β-cell along with other granular constituents including the …

Secretory granules are found in specialized cell types, including endocrine cells, suggesting
that a coordinated programme of gene expression is involved in their biogenesis. Indeed, it …

Expression of dense-core granules, a typical exocytic organelle, is widely believed to be
controlled by coordinate gene expression mechanisms specific to neurones and …

Processes underlying the formation of dense core secretory granules (DCGs) of
neuroendocrine cells are poorly understood. Here, we present evidence that DCG …

Chromogranin A (CgA) may be critical for secretory granule biogenesis in sympathoadrenal
cells. We found that silencing the expression of CgA reduced the number of secretory …

Secretory granules (SGs) are specialized organelles responsible for the storage and
regulated release of various biologically active molecules from the endocrine and exocrine …

Release of distinct cellular cargoes in response to specific stimuli is a process fundamental
to all higher eukaryotes and controlled by the regulated secretory pathway (RSP). However …