A new look at sodium channel β subunits
S Namadurai, NR Yereddi, FS Cusdin… - Open …, 2015 - royalsocietypublishing.org
Voltage-gated sodium (Nav) channels are intrinsic plasma membrane proteins that initiate
the action potential in electrically excitable cells. They are a major focus of research in …
the action potential in electrically excitable cells. They are a major focus of research in …
[HTML][HTML] Chromogranin A, an “on/off” switch controlling dense-core secretory granule biogenesis
We present evidence that regulation of dense-core secretory granule biogenesis and
hormone secretion in endocrine cells is dependent on chromogranin A (CGA) …
hormone secretion in endocrine cells is dependent on chromogranin A (CGA) …
β3: an additional auxiliary subunit of the voltage-sensitive sodium channel that modulates channel gating with distinct kinetics
K Morgan, EB Stevens, B Shah… - Proceedings of the …, 2000 - National Acad Sciences
The voltage-sensitive sodium channel confers electrical excitability on neurons, a
fundamental property required for higher processes including cognition. The ion-conducting …
fundamental property required for higher processes including cognition. The ion-conducting …
Trafficking/sorting and granule biogenesis in theβ-cell
M Molinete, JC Irminger, SA Tooze… - Seminars in cell & …, 2000 - Elsevier
Proinsulin is packaged into nascent (immature, clathrin-coated) secretory granules in the
trans-Golgi network (TGN) of the β-cell along with other granular constituents including the …
trans-Golgi network (TGN) of the β-cell along with other granular constituents including the …
Secretory granule biogenesis and chromogranin A: master gene, on/off switch or assembly factor?
R Day, SU Gorr - Trends in Endocrinology & Metabolism, 2003 - cell.com
Secretory granules are found in specialized cell types, including endocrine cells, suggesting
that a coordinated programme of gene expression is involved in their biogenesis. Indeed, it …
that a coordinated programme of gene expression is involved in their biogenesis. Indeed, it …
Dense-core granules: a specific hallmark of the neuronal/neurosecretory cell phenotype
ML Malosio, T Giordano, A Laslop… - Journal of cell …, 2004 - journals.biologists.com
Expression of dense-core granules, a typical exocytic organelle, is widely believed to be
controlled by coordinate gene expression mechanisms specific to neurones and …
controlled by coordinate gene expression mechanisms specific to neurones and …
[HTML][HTML] Pro-hormone secretogranin II regulates dense core secretory granule biogenesis in catecholaminergic cells
M Courel, A Soler-Jover, JL Rodriguez-Flores… - Journal of Biological …, 2010 - ASBMB
Processes underlying the formation of dense core secretory granules (DCGs) of
neuroendocrine cells are poorly understood. Here, we present evidence that DCG …
neuroendocrine cells are poorly understood. Here, we present evidence that DCG …
[HTML][HTML] Secretory granule biogenesis in sympathoadrenal cells: identification of a granulogenic determinant in the secretory prohormone chromogranin A
M Courel, C Rodemer, ST Nguyen, A Pance… - Journal of Biological …, 2006 - ASBMB
Chromogranin A (CgA) may be critical for secretory granule biogenesis in sympathoadrenal
cells. We found that silencing the expression of CgA reduced the number of secretory …
cells. We found that silencing the expression of CgA reduced the number of secretory …
Maturing secretory granules: where secretory and endocytic pathways converge
Secretory granules (SGs) are specialized organelles responsible for the storage and
regulated release of various biologically active molecules from the endocrine and exocrine …
regulated release of various biologically active molecules from the endocrine and exocrine …
The transcriptional repressor REST is a critical regulator of the neurosecretory phenotype
Release of distinct cellular cargoes in response to specific stimuli is a process fundamental
to all higher eukaryotes and controlled by the regulated secretory pathway (RSP). However …
to all higher eukaryotes and controlled by the regulated secretory pathway (RSP). However …