The development and progression of human cancers are continuously and dynamically
regulated by intrinsic and extrinsic factors. As a converging point of multiple oncogenic …

Stat3 is constitutively activated in many human cancers where it functions as a critical
mediator of oncogenic signaling through transcriptional activation of genes encoding …

Macrophages play a crucial role in tumorigenesis depending upon the phenotype of
macrophages found in tumor microenvironments. To date, how the tumor microenvironment …

The development of tyrosine phosphorylation inhibitors has transformed the approach to
cancer therapy and is likely to affect other fields of medicine. In spite of the conservation …

Numerous epidemiological studies documented that obesity is a risk factor for breast cancer
development in postmenopausal women. Leptin, the key player in the regulation of energy …

Sixteen flavonoids and related compounds have been tested for their ability to inhibit three
acidophilic Ser/Thr protein kinases: the Golgi apparatus casein kinase (G-CK) recently …

An increase in the risk of cancer is one of the consequences of obesity. The predominant
cancers associated with obesity have a hormonal basis and include breast, prostate …

Background. The aim of this review is to provide the information about molecular basis of
hypoxia-induced chemoresistance, focusing on the possibility of diagnostic and therapeutic …

Most of the signal transduction pathways are mediated by protein kinases regulating every
aspect of cell function. Mutations which deregulate their expression or their function or both …

Signal transducer and activator of transcription 3 (Stat3) has emerged as a critical regulator
for tumor-associated inflammation. Activation of Stat3 negatively regulates the Th1-type …