The role of STAT3 in leading the crosstalk between human cancers and the immune system
Y Wang, Y Shen, S Wang, Q Shen, X Zhou - Cancer letters, 2018 - Elsevier
The development and progression of human cancers are continuously and dynamically
regulated by intrinsic and extrinsic factors. As a converging point of multiple oncogenic …
regulated by intrinsic and extrinsic factors. As a converging point of multiple oncogenic …
Targeting Stat3 in cancer therapy
N Jing, DJ Tweardy - Anti-cancer drugs, 2005 - journals.lww.com
Stat3 is constitutively activated in many human cancers where it functions as a critical
mediator of oncogenic signaling through transcriptional activation of genes encoding …
mediator of oncogenic signaling through transcriptional activation of genes encoding …
[HTML][HTML] IL-6 influences the polarization of macrophages and the formation and growth of colorectal tumor
L Chen, S Wang, Y Wang, W Zhang, K Ma, C Hu… - Oncotarget, 2018 - ncbi.nlm.nih.gov
Macrophages play a crucial role in tumorigenesis depending upon the phenotype of
macrophages found in tumor microenvironments. To date, how the tumor microenvironment …
macrophages found in tumor microenvironments. To date, how the tumor microenvironment …
Tyrphostins and other tyrosine kinase inhibitors
A Levitzki, E Mishani - Annu. Rev. Biochem., 2006 - annualreviews.org
The development of tyrosine phosphorylation inhibitors has transformed the approach to
cancer therapy and is likely to affect other fields of medicine. In spite of the conservation …
cancer therapy and is likely to affect other fields of medicine. In spite of the conservation …
[HTML][HTML] Leptin-induced growth stimulation of breast cancer cells involves recruitment of histone acetyltransferases and mediator complex to CYCLIN D1 promoter via …
NK Saxena, PM Vertino, FA Anania… - Journal of Biological …, 2007 - ASBMB
Numerous epidemiological studies documented that obesity is a risk factor for breast cancer
development in postmenopausal women. Leptin, the key player in the regulation of energy …
development in postmenopausal women. Leptin, the key player in the regulation of energy …
Inhibition of protein kinase CK2 by flavonoids and tyrphostins. A structural insight
G Lolli, G Cozza, M Mazzorana, E Tibaldi, L Cesaro… - Biochemistry, 2012 - ACS Publications
Sixteen flavonoids and related compounds have been tested for their ability to inhibit three
acidophilic Ser/Thr protein kinases: the Golgi apparatus casein kinase (G-CK) recently …
acidophilic Ser/Thr protein kinases: the Golgi apparatus casein kinase (G-CK) recently …
[HTML][HTML] Leptin promotes the proliferative response and invasiveness in human endometrial cancer cells by activating multiple signal-transduction pathways
D Sharma, NK Saxena, PM Vertino… - Endocrine-related …, 2006 - erc.bioscientifica.com
An increase in the risk of cancer is one of the consequences of obesity. The predominant
cancers associated with obesity have a hormonal basis and include breast, prostate …
cancers associated with obesity have a hormonal basis and include breast, prostate …
[PDF][PDF] Hypoxia-induced chemoresistance in cancer cells: The role of not only HIF-1.
H Doktorova, J Hrabeta, MA Khalil… - … Papers of the …, 2015 - pdfs.semanticscholar.org
Background. The aim of this review is to provide the information about molecular basis of
hypoxia-induced chemoresistance, focusing on the possibility of diagnostic and therapeutic …
hypoxia-induced chemoresistance, focusing on the possibility of diagnostic and therapeutic …
Protein kinase inhibitors as a therapeutic modality
A Levitzki - Accounts of chemical research, 2003 - ACS Publications
Most of the signal transduction pathways are mediated by protein kinases regulating every
aspect of cell function. Mutations which deregulate their expression or their function or both …
aspect of cell function. Mutations which deregulate their expression or their function or both …
STAT3: a target to enhance antitumor immune response
H Lee, SK Pal, K Reckamp, RA Figlin, H Yu - Cancer Immunology and …, 2011 - Springer
Signal transducer and activator of transcription 3 (Stat3) has emerged as a critical regulator
for tumor-associated inflammation. Activation of Stat3 negatively regulates the Th1-type …
for tumor-associated inflammation. Activation of Stat3 negatively regulates the Th1-type …