Although the potential contribution of the human gastrointestinal (GI) tract microbiome to
human health, aging, and disease is becoming increasingly acknowledged, the molecular …

Traumatic brain injury (TBI) is one of the significant causes of death and morbidity, and it is
hence a focus of translational research. Apoptosis plays an essential part in the …

Emergence of castration-resistant metastatic prostate cancer is due to activation of survival
pathways, including apoptosis suppression and anoikis resistance, and increased …

Purpose.: Drusen are hallmarks of age-related macular degeneration (AMD). Amyloid-beta 1-
40 (Aβ 1-40), a constituent of drusen, is known to stimulate inflammatory pathways in RPE; …

During the past two decades, apoptotic cell death has been the subject of an intense wave
of investigation, leading to the discovery of multiple gene products that govern both its …

Alzheimer's disease (AD) is a neurodegenerative disease, characterized histopathologically
by intra-neuronal tau-related lesions and by the accumulation of amyloid β-peptide (Aβ) in …

Background Human periodontal ligament (PDL) cells underwent apoptosis after mechanical
stretch loading. However, the exact signalling pathway remains unknown. This study aimed …

Inflammasomes are cytosolic multi-molecular complexes that sense intracellular microbial
danger signals and metabolic perturbations. Inflammasome activation leads to the activation …

Chronic vascular inflammation is a key hallmark in the pathogenesis of abdominal aortic
aneurysm (AAA). Recent investigations have suggested that the inflammasome, a cytosolic …

Intracellular membranes composing organelles of eukaryotes include membrane proteins
playing crucial roles in physiological functions. However, a comprehensive understanding of …