Chemoresistance to the anticancer therapy is the main challenge for the recurrence of
cancer and it is responsible for treatment failure and unfavorable clinical outcome …

Since its initial discovery in Drosophila, Hedgehog (HH) signaling has long been associated
with foregut development. The mammalian genome expresses 3 HH ligands, with sonic …

Purpose: Gastric cancers may harbor a subset of cells with cancer stem cell (CSC)
properties, including chemotherapy resistance, and CD44 is a gastric CSC marker. The …

Hedgehog ligands control tissue development and homeostasis by alleviating repression of
Smoothened, a seven-pass transmembrane protein. The Hedgehog receptor, Patched, is …

Objective: To review vismodegib, the first Food and Drug Administration (FDA)-approved
Hedgehog (Hh) signaling pathway inhibitor, in the treatment of advanced basal cell …

Highlights•Hedgehog signaling regulates gastric physiology, regeneration, and
disease.•Sonic Hedgehog is secreted from the gastric parietal cells.•The dysregulation of …

Small-molecule inhibitors targeted MAPK have been wildly used for some cancer
therapeutics as a biologically viable model, but no one has been used for cervical caner …

In the past decade, the therapeutic potential of arsenic trioxide (ATO) in the treatment of
acute promyelocytic leukemia (APL) was recognized. This encouraged other investigators to …

Plants belonging to the genus Veratrum have been used throughout history for their
medicinal properties. During the nineteenth and twentieth centuries, phytochemical …

Hedgehog (Hh) signaling is a highly conserved intercellular and intracellular communication
mechanism that governs organogenesis and is dysregulated in cancers of numerous …