Dexmedetomidin is a new-generation, highly selective α2 adrenergic receptor agonist with a
large number of advantages, including its sedative and analgesic properties, its ability to …

The key role of pro-inflammatory cytokines in the pathogenesis of rheumatoid arthritis (RA)
and psoriatic arthritis (PsA) is strongly supported by the observation that their blockage is …

Tryptophan (TRP) is an essential, aromatic amino acid catabolized by indoleamine 2, 3-
dioxygenase (IDO) and tryptophan 2, 3-dioxygenase (TDO) enzymes into kynurenine. The …

Neuroinflammatory disorders preferentially impair the higher cognitive and executive
functions of the prefrontal cortex (PFC). This includes such challenging disorders as …

Neuropathic pain remains a therapeutic challenge because of its complicated mechanisms.
Mas-related GPCR D (MrgprD) is specifically expressed in small-diameter, nociceptive …

The aim of the present study was to investigate the mechanism by which dexmedetomidine
(DEX) alleviates neuropathic pain in a chronic constriction injury (CCI) model in rats. A CCI …

Concern was raised about the reliability of the images in Figure 2 and the cell cycle data in
Figure 7, as detailed here: https://pubpeer. com/publications …

Sepsis‑associated encephalopathy (SAE) is characterized by neuronal apoptosis and
changes in mental status. Accumulating evidence has. indicated that dexmedetomidine is …

Antidepressants, prescribed as first line treatment of neuropathic pain, have a limited
efficacy and poorly tolerated side effects. Because recent studies pointed out the implication …

Detection of cold allodynia is a very important aspect in the study of pain behavior. An
effective and concise device for detecting cold pain has always been the hope of many …