Gliomas are the most common central nervous system tumors. New technologies, including
genetic research and advanced statistical methods, revolutionize the therapeutic approach …

Over the last decade, developments in molecular profiling have radically altered the
diagnosis, classification, and management of numerous cancer types, with primary brain …

Abstract The Central Brain Tumor Registry of the United States (CBTRUS), in collaboration
with the Centers for Disease Control and Prevention and National Cancer Institute, is the …

The NCCN Guidelines for Central Nervous System (CNS) Cancers focus on management of
adult CNS cancers ranging from noninvasive and surgically curable pilocytic astrocytomas …

Genome-wide molecular-profiling studies have revealed the characteristic genetic
alterations and epigenetic profiles associated with different types of gliomas. These …

Gliomas are the most common primary intracranial tumor, representing 81% of malignant
brain tumors. Although relatively rare, they cause significant mortality and morbidity …

Grade II and III gliomas are generally slowly progressing brain cancers, many of which
eventually transform into more aggressive tumors. Despite recent findings of frequent …

EGFR amplification (EGFR amp), the combination of gain of chromosome 7 and loss of
chromosome 10 (7+/10−), and TERT promoter mutation (p TERT mut) are alterations …

This guideline provides recommendations for diagnostic and therapeutic procedures for
patients with malignant gliomas. We differentiate evidence-based standards from …

The “integrated diagnosis” for infiltrating gliomas in the 2016 revised World Health
Organization (WHO) classification of tumors of the central nervous system requires …