Neurodegenerative diseases are a group of pathological conditions that cause motor inc-
ordination (jerking movements), cognitive and memory impairments result from …

Histone deacetylase 8 (HDAC8) is a class I HDAC that catalyzes the deacetylation of histone
and non-histone proteins. As one of the best-characterized isoforms, numerous studies have …

Neurodevelopmental disorders (NDDs), including intellectual disability (ID) and autism
spectrum disorders (ASD), are a large group of disorders in which early insults during brain …

In inflammatory neuropathies, oxidative stress results in neuronal and Schwann cell (SC)
death promoting early neurodegeneration and clinical disability. Treatment with the short …

Abstract Histone deacetylase 8 (HDAC8) aberrantly deacetylates histone and non-histone
proteins. These include structural maintenance of chromosome 3 (SMC3) cohesin protein …

Acetylation is a key post-translational modification (PTM) involved in the regulation of both
histone and non-histone proteins. It controls cellular processes such as DNA transcription …

Histone deacetylases (HDACs) are epigenetic enzymes which participate in transcriptional
repression and chromatin condensation mechanisms by removing the acetyl moiety from …

Abstract Background Spermatogonia Stem Cells (SSCs) are potential candidates for
reprogramming and regeneration. Recent studies have revealed that differentiated cells can …

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease. ALS
patients suffer from a progressive loss of motor neurons, leading to respiratory failure within …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with multiple complex
mechanisms involved. Among them, mitochondrial dysfunction plays an important role in …