Structural diversity, characterization and toxicology of microcystins
N Bouaïcha, CO Miles, DG Beach, Z Labidi, A Djabri… - Toxins, 2019 - mdpi.com
Hepatotoxic microcystins (MCs) are the most widespread class of cyanotoxins and the one
that has most often been implicated in cyanobacterial toxicosis. One of the main challenges …
that has most often been implicated in cyanobacterial toxicosis. One of the main challenges …
Tau pathology and neurodegeneration
MG Spillantini, M Goedert - The Lancet Neurology, 2013 - thelancet.com
The pathway leading from soluble and monomeric to hyperphosphorylated, insoluble and
filamentous tau protein is at the centre of many human neurodegenerative diseases …
filamentous tau protein is at the centre of many human neurodegenerative diseases …
Structural basis of Integrator-mediated transcription regulation
Integrator and protein phosphatase 2A (PP2A) form a complex that dephosphorylates
paused RNA polymerase II (Pol II), cleaves the nascent RNA, and terminates transcription …
paused RNA polymerase II (Pol II), cleaves the nascent RNA, and terminates transcription …
Identification of Integrator-PP2A complex (INTAC), an RNA polymerase II phosphatase
INTRODUCTION RNA cleavage and phosphorylation-dephosphorylation of the RNA
polymerase II (Pol II) C-terminal domain (CTD) are two regulatory mechanisms of …
polymerase II (Pol II) C-terminal domain (CTD) are two regulatory mechanisms of …
Integrator recruits protein phosphatase 2A to prevent pause release and facilitate transcription termination
Efficient release of promoter-proximally paused RNA Pol II into productive elongation is
essential for gene expression. Recently, we reported that the Integrator complex can bind …
essential for gene expression. Recently, we reported that the Integrator complex can bind …
PP2A as a master regulator of the cell cycle
N Wlodarchak, Y Xing - Critical reviews in biochemistry and …, 2016 - Taylor & Francis
Abstract Protein phosphatase 2A (PP2A) plays a critical multi-faceted role in the regulation
of the cell cycle. It is known to dephosphorylate over 300 substrates involved in the cell …
of the cell cycle. It is known to dephosphorylate over 300 substrates involved in the cell …
Targeted dephosphorylation of tau by phosphorylation targeting chimeras (PhosTACs) as a therapeutic modality
Microtubule-associated protein tau is essential for microtubule assembly and stabilization.
Hyperphosphorylation of the microtubule-associated protein tau plays an important …
Hyperphosphorylation of the microtubule-associated protein tau plays an important …
All roads lead to PP 2A: exploiting the therapeutic potential of this phosphatase
J Sangodkar, CC Farrington, K McClinch… - The FEBS …, 2016 - Wiley Online Library
Protein phosphatase 2A (PP 2A) is a serine/threonine phosphatase involved in the
regulation of many cellular processes. A confirmed tumor suppressor protein, PP 2A is …
regulation of many cellular processes. A confirmed tumor suppressor protein, PP 2A is …
Post-translational modifications of tau protein: implications for Alzheimer's disease
L Martin, X Latypova, F Terro - Neurochemistry international, 2011 - Elsevier
Alzheimer's disease (AD) belongs to a group of neurodegenerative diseases collectively
designated as “tauopathies”, because they are characterized by the aggregation of …
designated as “tauopathies”, because they are characterized by the aggregation of …
Serine/threonine phosphatases: mechanism through structure
Y Shi - Cell, 2009 - cell.com
The reversible phosphorylation of proteins is accomplished by opposing activities of kinases
and phosphatases. Relatively few protein serine/threonine phosphatases (PSPs) control the …
and phosphatases. Relatively few protein serine/threonine phosphatases (PSPs) control the …