Current understanding of the molecular mechanisms of circulating permeability factor in focal segmental glomerulosclerosis
The pathogenetic mechanisms underlying the onset and the post-transplant recurrence of
primary focal segmental glomerulosclerosis (FSGS) are complex and remain yet to be fully …
primary focal segmental glomerulosclerosis (FSGS) are complex and remain yet to be fully …
The complement C3a and C3a receptor pathway in kidney diseases
S Gao, Z Cui, M Zhao - Frontiers in immunology, 2020 - frontiersin.org
The pathogenesis of some kidney diseases is closely associated with complement
activation, where the C3a/C3a receptor (C3aR) might play a crucial role. C3a/C3aR has …
activation, where the C3a/C3a receptor (C3aR) might play a crucial role. C3a/C3aR has …
[HTML][HTML] SGLT2 inhibitor dapagliflozin limits podocyte damage in proteinuric nondiabetic nephropathy
P Cassis, M Locatelli, D Cerullo, D Corna, S Buelli… - JCI insight, 2018 - ncbi.nlm.nih.gov
Abstract Sodium-glucose cotransporter 2 (SGLT2) inhibitors have pleiotropic properties
beyond blood glucose–lowering effects and modify important nonglycemic pathways …
beyond blood glucose–lowering effects and modify important nonglycemic pathways …
SARS-CoV-2 spike protein induces lung endothelial cell dysfunction and thrombo-inflammation depending on the C3a/C3a receptor signalling
The spike protein of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) can
interact with endothelial cells. However, no studies demonstrated the direct effect of the …
interact with endothelial cells. However, no studies demonstrated the direct effect of the …
[HTML][HTML] C3a receptor blockade protects podocytes from injury in diabetic nephropathy
Renal activation of the complement system has been described in patients with diabetic
nephropathy (DN), although its pathological relevance is still ill-defined. Here, we studied …
nephropathy (DN), although its pathological relevance is still ill-defined. Here, we studied …
Loss of decay-accelerating factor triggers podocyte injury and glomerulosclerosis
A Angeletti, C Cantarelli, A Petrosyan… - Journal of Experimental …, 2020 - rupress.org
Kidney glomerulosclerosis commonly progresses to end-stage kidney failure, but
pathogenic mechanisms are still poorly understood. Here, we show that podocyte …
pathogenic mechanisms are still poorly understood. Here, we show that podocyte …
Therapeutic potential of stromal cells of non-renal or renal origin in experimental chronic kidney disease
Background Mesenchymal stromal cell (MSC)-based therapy is a promising strategy for
preventing the progression of chronic kidney disease (CKD), with the potential to induce …
preventing the progression of chronic kidney disease (CKD), with the potential to induce …
Serum protein pattern associated with organ damage and lupus nephritis in systemic lupus erythematosus revealed by PEA immunoassay
A Petrackova, A Smrzova, P Gajdos, M Schubertova… - Clinical proteomics, 2017 - Springer
Background Systemic lupus erythematosus (SLE) is a remarkably heterogeneous
autoimmune disease. Despite tremendous efforts, our knowledge of serum protein patterns …
autoimmune disease. Despite tremendous efforts, our knowledge of serum protein patterns …
Shiga toxin triggers endothelial and podocyte injury: the role of complement activation
Abstract Shiga toxin (Stx)-producing Escherichia coli (STEC) is the offending agent in post-
diarrhea-associated hemolytic uremic syndrome (HUS), a disorder characterized by …
diarrhea-associated hemolytic uremic syndrome (HUS), a disorder characterized by …
Parietal epithelial cell dysfunction in crescentic glomerulonephritis
MN Wong, PL Tharaux, F Grahammer… - Cell and Tissue …, 2021 - Springer
Crescentic glomerulonephritis represents a group of kidney diseases characterized by rapid
loss of kidney function and the formation of glomerular crescents. While the role of the …
loss of kidney function and the formation of glomerular crescents. While the role of the …