Native mass spectrometry: recent progress and remaining challenges

KR Karch, DT Snyder, SR Harvey… - Annual review of …, 2022 - annualreviews.org
Native mass spectrometry (nMS) has emerged as an important tool in studying the structure
and function of macromolecules and their complexes in the gas phase. In this review, we …

Applications of charge detection mass spectrometry in molecular biology and biotechnology

MF Jarrold - Chemical reviews, 2021 - ACS Publications
Charge detection mass spectrometry (CDMS) is a single-particle technique where the
masses of individual ions are determined from simultaneous measurement of their mass-to …

Approaches to heterogeneity in native mass spectrometry

AD Rolland, JS Prell - Chemical reviews, 2021 - ACS Publications
Native mass spectrometry (MS) is aimed at preserving and determining the native structure,
composition, and stoichiometry of biomolecules and their complexes from solution after they …

Higher resolution charge detection mass spectrometry

AR Todd, LF Barnes, K Young, A Zlotnick… - Analytical …, 2020 - ACS Publications
Charge detection mass spectrometry is a single particle technique where the masses of
individual ions are determined from simultaneous measurements of each ion'sm/z ratio and …

Exploring the structure and dynamics of macromolecular complexes by native mass spectrometry

EB Erba, L Signor, C Petosa - Journal of proteomics, 2020 - Elsevier
Mass spectrometry (MS) is an effective approach for determining the mass of biomolecules
with high accuracy, sensitivity and speed. Over the past 25 years, MS performed under non …

Implementation of a charge-sensitive amplifier without a feedback resistor for charge detection mass spectrometry reduces noise and enables detection of individual …

AR Todd, AW Alexander, MF Jarrold - Journal of the American …, 2019 - ACS Publications
Charge detection mass spectrometry (CDMS) depends on the measurement of the charge
induced on a cylinder by individual ions by means of a charge-sensitive amplifier. Electrical …

Analysis of recombinant adenovirus vectors by ion trap charge detection mass spectrometry: accurate molecular weight measurements beyond 150 MDa

LF Barnes, BE Draper, MF Jarrold - Analytical Chemistry, 2022 - ACS Publications
Adenovirus is one of the largest nonenveloped, double-stranded DNA viruses. It is widely
used as a gene therapy vector and has recently received a lot of attention as a novel vaccine …

Differential viral RNA methylation contributes to pathogen blocking in Wolbachia-colonized arthropods

T Bhattacharya, L Yan, JM Crawford, H Zaher… - PLoS …, 2022 - journals.plos.org
Arthropod endosymbiont Wolbachia pipientis is part of a global biocontrol strategy to reduce
the replication of mosquito-borne RNA viruses such as alphaviruses. We previously …

Dynamic calibration enables high-accuracy charge measurements on individual ions for charge detection mass spectrometry

AR Todd, MF Jarrold - Journal of the American Society for Mass …, 2020 - ACS Publications
Charge detection mass spectrometry (CDMS) depends on the measurement of the charge
induced on a cylinder by individual ions by means of a charge-sensitive amplifier. For high …

Current understanding of the role of cholesterol in the life cycle of alphaviruses

IP Sousa Jr, CAM Carvalho, AMO Gomes - Viruses, 2020 - mdpi.com
Enveloped viruses rely on different lipid classes present in cell membranes to accomplish
several steps of their life cycle in the host. Particularly for alphaviruses, a medically important …