Native mass spectrometry: recent progress and remaining challenges
Native mass spectrometry (nMS) has emerged as an important tool in studying the structure
and function of macromolecules and their complexes in the gas phase. In this review, we …
and function of macromolecules and their complexes in the gas phase. In this review, we …
Applications of charge detection mass spectrometry in molecular biology and biotechnology
MF Jarrold - Chemical reviews, 2021 - ACS Publications
Charge detection mass spectrometry (CDMS) is a single-particle technique where the
masses of individual ions are determined from simultaneous measurement of their mass-to …
masses of individual ions are determined from simultaneous measurement of their mass-to …
Approaches to heterogeneity in native mass spectrometry
AD Rolland, JS Prell - Chemical reviews, 2021 - ACS Publications
Native mass spectrometry (MS) is aimed at preserving and determining the native structure,
composition, and stoichiometry of biomolecules and their complexes from solution after they …
composition, and stoichiometry of biomolecules and their complexes from solution after they …
Higher resolution charge detection mass spectrometry
AR Todd, LF Barnes, K Young, A Zlotnick… - Analytical …, 2020 - ACS Publications
Charge detection mass spectrometry is a single particle technique where the masses of
individual ions are determined from simultaneous measurements of each ion'sm/z ratio and …
individual ions are determined from simultaneous measurements of each ion'sm/z ratio and …
Exploring the structure and dynamics of macromolecular complexes by native mass spectrometry
Mass spectrometry (MS) is an effective approach for determining the mass of biomolecules
with high accuracy, sensitivity and speed. Over the past 25 years, MS performed under non …
with high accuracy, sensitivity and speed. Over the past 25 years, MS performed under non …
Implementation of a charge-sensitive amplifier without a feedback resistor for charge detection mass spectrometry reduces noise and enables detection of individual …
AR Todd, AW Alexander, MF Jarrold - Journal of the American …, 2019 - ACS Publications
Charge detection mass spectrometry (CDMS) depends on the measurement of the charge
induced on a cylinder by individual ions by means of a charge-sensitive amplifier. Electrical …
induced on a cylinder by individual ions by means of a charge-sensitive amplifier. Electrical …
Analysis of recombinant adenovirus vectors by ion trap charge detection mass spectrometry: accurate molecular weight measurements beyond 150 MDa
LF Barnes, BE Draper, MF Jarrold - Analytical Chemistry, 2022 - ACS Publications
Adenovirus is one of the largest nonenveloped, double-stranded DNA viruses. It is widely
used as a gene therapy vector and has recently received a lot of attention as a novel vaccine …
used as a gene therapy vector and has recently received a lot of attention as a novel vaccine …
Differential viral RNA methylation contributes to pathogen blocking in Wolbachia-colonized arthropods
Arthropod endosymbiont Wolbachia pipientis is part of a global biocontrol strategy to reduce
the replication of mosquito-borne RNA viruses such as alphaviruses. We previously …
the replication of mosquito-borne RNA viruses such as alphaviruses. We previously …
Dynamic calibration enables high-accuracy charge measurements on individual ions for charge detection mass spectrometry
AR Todd, MF Jarrold - Journal of the American Society for Mass …, 2020 - ACS Publications
Charge detection mass spectrometry (CDMS) depends on the measurement of the charge
induced on a cylinder by individual ions by means of a charge-sensitive amplifier. For high …
induced on a cylinder by individual ions by means of a charge-sensitive amplifier. For high …
Current understanding of the role of cholesterol in the life cycle of alphaviruses
IP Sousa Jr, CAM Carvalho, AMO Gomes - Viruses, 2020 - mdpi.com
Enveloped viruses rely on different lipid classes present in cell membranes to accomplish
several steps of their life cycle in the host. Particularly for alphaviruses, a medically important …
several steps of their life cycle in the host. Particularly for alphaviruses, a medically important …