Aberrant DNA methylation plays a pivotal role in tumor development and progression. DNA
hypomethylating agents (HMA) constitute a class of drugs which are able to reverse DNA …

Abstract Disease Overview Chronic myelomonocytic leukemia (CMML) is a clonal
hematopoietic stem cell disorder with overlapping features of myelodysplastic syndromes …

Myeloid neoplasms and acute leukemias derive from the clonal expansion of hematopoietic
cells driven by somatic gene mutations. Although assessment of morphology plays a crucial …

Somatic mutations in cancer genomes are caused by multiple mutational processes, each of
which generates a characteristic mutational signature. Here, as part of the Pan-Cancer …

Somatic gain-of-function mutations in isocitrate dehydrogenases (IDH) 1 and 2 are found in
multiple hematologic and solid tumors, leading to accumulation of the oncometabolite (R)-2 …

To elucidate differential roles of mutations in myelodysplastic syndromes (MDS), we
investigated clonal dynamics using whole-exome and/or targeted sequencing of 699 …

INTRODUCTION Gene fusions are often disease-defining events in cancer. The mutational
processes that give rise to fusions, their timing relative to initial diagnosis, and whether they …

Oncogenic Ras mutations occur in various leukemias. It was unclear if, besides the direct
transforming effect via constant RAS/MEK/ERK signaling, an inflammation-related effect of …

Somatic mutations in cancer genomes are caused by multiple mutational processes each of
which generates a characteristic mutational signature. Using 84,729,690 somatic mutations …

The azanucleosides azacitidine and decitabine are currently used for the treatment of acute
myeloid leukemia (AML) and myelodysplastic syndromes (MDS) in patients not only eligible …