Akt kinase, a member of AGC kinases, is important in many cellular functions including
proliferation, migration, cell growth and metabolism. There are three known Akt isoforms …

TOR (target of rapamycin) and its mammalian ortholog mTOR have been discovered in an
effort to understand the mechanisms of action of the immunosuppressant drug rapamycin …

The unique metabolic demands of cancer cells underscore potentially fruitful opportunities
for drug discovery in the era of precision medicine. However, therapeutic targeting of cancer …

Trained immunity is a process in which innate immune cells undergo functional
reprogramming in response to pathogens or damage‐associated molecules leading to an …

Asymptomatic hyperuricaemia affects~ 20% of the general population in the USA, with
variable rates in other countries. Historically, asymptomatic hyperuricaemia was considered …

The mTOR pathway was discovered in the late 1970s after the compound and natural
inhibitor of mTOR, rapamycin was isolated from the bacterium Streptomyces hygroscopicus …

Metabolic triggers are important inducers of the inflammatory processes in gout. Whereas
the high serum urate levels observed in patients with gout predispose them to the formation …

Simple Summary The concentration of uric acid in blood is sex-, age-and diet-dependent
and is maintained close to its maximal solubility, indicating that it plays some important role …

Skeletal muscle mass is, in part, regulated by the rate of mRNA translation (ie, protein
synthesis). The conserved serine/threonine kinase, mTOR (the mammalian/mechanistic …

Non-small-cell lung cancer patients with activating epidermal growth factor receptor (EGFR)
mutations typically benefit from EGFR tyrosine kinase inhibitor treatment. However, virtually …