The way in which cells coordinate their behaviours during various biological processes,
including morphogenesis, cancer progression and tissue remodelling, largely depends on …

Tissue and organ development during embryogenesis relies on the collective and
coordinated action of many cells. Recent studies have revealed that tissue material …

Chemical and physical properties of the environment control cell proliferation, differentiation,
or apoptosis in the long term. However, to be able to move and migrate through a complex …

The cadherin-catenin adhesion complex is the key component of the intercellular adherens
junction (AJ) that contributes both to tissue stability and dynamic cell movements in epithelial …

It is increasingly clear that mechanotransduction pathways play important roles in regulating
fundamental cellular functions. Of the basic mechanical functions, the determination of …

The generation of organismal form—morphogenesis—arises from forces produced at the
cellular level. In animal cells, much of this force is produced by the actin cytoskeleton. Here …

The cell–cell connections in adherens junctions (AJs) are mediated by transmembrane
receptors, type I cadherins (referred to here as cadherins). These cadherin-based …

Multicellularity in animals requires dynamic maintenance of cell–cell contacts. Intercellularly
ligated cadherins recruit numerous proteins to form supramolecular complexes that connect …

Adherens junctions (AJs) are molecular complexes that mediate cell-cell adhesive
interactions and play pivotal roles in maintenance of tissue organization in adult organisms …

Adherens junctions (AJs) are mechanosensitive cadherin-based intercellular adhesions that
interact with the actin cytoskeleton and carry most of the mechanical load at cell–cell …