The concept of strain in organic compounds is as old as modern organic chemistry and was
initially introduced to justify the synthetic setbacks along the synthesis of small ring systems …

Bicyclobutanes are among the most highly strained isolable organic compounds and their
associated low activation barriers to reactivity make them intriguing building-blocks in …

Dearomative photocycloadditions are valuable chemical transformations, serving as an
efficient platform to create three-dimensional molecular complexity. However, the …

Benzenes, the most ubiquitous structural moiety in marketed small-molecule drugs, are
frequently associated with poor 'drug-like'properties, including metabolic instability, and poor …

The unique chemistry of small, strained carbocyclic systems has long captivated organic
chemists from a theoretical and fundamental standpoint. A resurgence of interest in strained …

Azabicyclo [2.1. 1] hexanes (aza-BCHs) and bicyclo [1.1. 1] pentanes (BCPs) have emerged
as attractive classes of sp 3-rich cores for replacing flat, aromatic groups with metabolically …

Enantioenriched organoboron intermediates are important building blocks in organic
synthesis and drug discovery. Recently, transition metal-catalyzed enantioselective 1, 2 …

Three-and four-membered rings, widespread motifs in nature and medicinal chemistry, have
fascinated chemists ever since their discovery. However, due to energetic considerations …

Abstract Bicyclic hydrocarbons, and bicyclo [1.1. 1] pentanes (BCPs) in particular, are
playing an emerging role as saturated bioisosteres in pharmaceutical, agrochemical and …

We report the first palladium hydride enabled hydroalkenylation of strained molecules. This
new mild protocol proceeds via a regio-and chemoselective hydropalladation step, followed …