Copper in diseases and treatments, and copper‐based anticancer strategies

F Tisato, C Marzano, M Porchia… - Medicinal research …, 2010 - Wiley Online Library
Copper is found in all living organisms and is a crucial trace element in redox chemistry,
growth and development. It is important for the function of several enzymes and proteins …

Copper complexes as anticancer agents

C Marzano, M Pellei, F Tisato… - Anti-Cancer Agents in …, 2009 - ingentaconnect.com
Metal-based antitumor drugs play a relevant role in antiblastic chemotherapy. Cisplatin is
regarded as one of the most effective drugs, even if severe toxicities and drug resistance …

What is holding back the development of antiviral metallodrugs? A literature overview and implications for SARS-CoV-2 therapeutics and future viral outbreaks

REF de Paiva, AM Neto, IA Santos, ACG Jardim… - Dalton …, 2020 - pubs.rsc.org
In light of the Covid-19 outbreak, this review brings together historical and current literature
efforts towards the development of antiviral metallodrugs. Classical compounds such as …

Ternary dinuclear copper (II) complexes of a hydroxybenzamide ligand with diimine coligands: the 5, 6-dmp ligand enhances DNA binding and cleavage and induces …

S Ramakrishnan, D Shakthipriya, E Suresh… - Inorganic …, 2011 - ACS Publications
The dinuclear copper (II) complexes [Cu2 (LH) 2 (diimine) 2 (ClO4) 2](ClO4) 2 (1–4), where
LH= 2-hydroxy-N-[2-(methylamino) ethyl] benzamide and diimine= 2, 2′-bipyridine (bpy; 1) …

Mixed-ligand copper (II) maltolate complexes: synthesis, characterization, DNA binding and cleavage, and cytotoxicity

A Barve, A Kumbhar, M Bhat, B Joshi… - Inorganic …, 2009 - ACS Publications
The mixed-ligand complexes [Cu (L)(maltol)] where L= 2, 2′-bipyridine (bpy; 1), 1, 10-
phenanthroline (phen; 2), 1, 10-phenanthroline-5, 6-dione (phendione; 3), dipyrido [3, 2-a …

Novel Copper(II) Complex of N-Propyl-norfloxacin and 1,10-Phenanthroline with Enhanced Antileukemic and DNA Nuclease Activities

ME Katsarou, EK Efthimiadou, G Psomas… - Journal of medicinal …, 2008 - ACS Publications
We have synthesized and characterized a novel copper (II) complex of the fluoroquinolone
antibacterial drug N-propyl-norfloxacin (Hpr-norf) in the presence of 1, 10-phenanthroline …

Antimicrobial and SOD activities of novel transition metal complexes of pyridine-2, 6-dicarboxylic acid containing 4-picoline as auxiliary ligand

ZA Siddiqi, M Khalid, S Kumar, M Shahid… - European journal of …, 2010 - Elsevier
Ternary complexes are potential models for several mono and polynuclear metal enzymes.
The present ternary complexes [Fe (dipic)(4-picoline)] Cl,[M (dipic)(4-picoline)][M= Co or Ni] …

Mixed-ligand copper (II) Schiff base complexes: the vital role of co-ligands in DNA/protein interactions and cytotoxicity

S Kathiresan, S Mugesh, J Annaraj… - New Journal of …, 2017 - pubs.rsc.org
A series of four new mixed-ligand copper (II) complexes (1–4) of the type [Cu
(L)(diimine)](ClO4)[where L is 2-((1H-imidazol-2-yl) methylene)-N …

Mixed-ligand copper (II) complexes of dipicolylamine and 1, 10-phenanthrolines: The role of diimines in the interaction of the complexes with DNA

S Ramakrishnan, M Palaniandavar - Journal of Chemical Sciences, 2005 - Springer
Mixed-ligand copper (II) complexes of the type [Cu (dipica)(diimine)](ClO 4) 2, where dipica
is di (2-picolyl) amine and diimine is 1, 10-phenanthroline (phen), 5, 6-dimethyl-1, 10 …

Synthesis and anti-Candida activity of copper (II) and manganese (II) carboxylate complexes: X-ray crystal structures of [Cu (sal)(bipy)]· C2H5OH· H2O and [Cu (norb) …

M Geraghty, V Sheridan, M McCann, M Devereux… - Polyhedron, 1999 - Elsevier
The copper (II) complexes [Cu (salH) 2 (H2O) 2]· 0.5 H2O (1)(salH2= salicylic acid) and [Cu2
(asp) 4]· 3H2O (8){aspH= acetylsalicylic acid (aspirin)} both react with imidazole (imid), 1, 10 …