Parkinson's disease (PD) is the second most predominant neurodegenerative disease
worldwide. It is recognized clinically by severe complications in motor function caused by …

Background Stem cells hold tremendous promise for regenerative medicine because they
can be expanded infinitely, giving rise to large numbers of differentiated cells required for …

Telomeres are specialized nucleoprotein structures at the ends of linear chromosomes. The
progressive shortening of steady-state telomere length in normal human somatic cells is a …

In the context of a continuously increased delay of motherhood and of an increase of the
incidence of premature ovarian failure, it is of the greatest interest to dispose of a predictive …

Embryonic stem cells (ESCs), somatic cell nuclear transfer ESCs, and induced pluripotent
stem cells (iPSCs) represent the most studied group of PSCs. Unlimited self-renewal without …

The repression of telomerase activity during cellular differentiation promotes replicative
aging and functions as a physiological barrier for tumorigenesis in long-lived mammals …

Mutations in the TINF2 gene, encoding the shelterin protein TIN2, cause telomere
shortening and the inherited bone marrow (BM) failure syndrome dyskeratosis congenita …

Shorter peripheral blood leukocyte (PBL) telomere length (TL) has been associated with
poor outcomes in various chronic lung diseases. Whether PBL-TL is associated with survival …

Simple Summary Pancreatic ductal adenocarcinoma (PDAC) is an extremely lethal cancer
with very limited therapeutic options. Cancer stem cells (CSCs) are essential for propagation …

Pluripotent stem cells (PSCs) are a promising source of stem cells for regenerative
therapies. Stem cell function depends on telomere maintenance mechanisms that provide …