Macrophages are increasingly recognized as essential players in the maintenance of
intestinal homeostasis and as key sentinels of the intestinal immune system. However …

Helminth parasite infections are associated with a battery of immunomodulatory
mechanisms that affect all facets of the host immune response to ensure their persistence …

Helminth endemic regions report lower COVID-19 morbidity and mortality. Here, we show
that lung remodeling from a prior infection with a lung-migrating helminth, Nippostrongylus …

In fracture healing, skeletal and immune system are closely interacting through common cell
precursors and molecular mediators. It is thought that the initial inflammatory reaction, which …

The intestine contains the largest pool of macrophages in the body which are essential for
maintaining mucosal homeostasis in the face of the microbiota and the constant need for …

Recent studies have demonstrated that many parasites release extracellular vesicles (EVs),
yet little is known about the specific interactions of EVs with immune cells or their functions …

The intestinal lamina propria (LP) contains a diverse array of mononuclear phagocyte (MNP)
subsets, including conventional dendritic cells (cDC), monocytes and tissue-resident …

The intestinal microbiota are pivotal in determining the developmental, metabolic and
immunological status of the mammalian host. However, the intestinal tract may also …

Immunity to many human and murine gastrointestinal helminth parasites requires interleukin-
4 (IL-4)-directed type 2 helper (TH 2) differentiation of CD4+ T cells to elicit type-2 immunity …

Metazoan parasites typically induce a type 2 immune response, characterized by T helper 2
(Th2) cells that produce the cytokines IL-4, IL-5 and IL-13 among others. The type 2 …