Intrarenal autoregulatory mechanisms maintain renal blood flow (RBF) and glomerular
filtration rate (GFR) independent of renal perfusion pressure (RPP) over a defined range (80 …

P2X receptors are membrane cation channels gated by extracellular ATP. Seven P2X
receptor subunits (P2X1-7) are widely distributed in excitable and nonexcitable cells of …

Purinergic signaling was proposed in 1972, after it was demonstrated that adenosine 5′-
triphosphate (ATP) was a transmitter in nonadrenergic, noncholinergic inhibitory nerves …

Abstract ATP-gated P2X receptors are trimeric ion channels that assemble as homo-or
heteromers from seven cloned subunits. Transcripts and/or proteins of P2X subunits have …

Purines appear to be the most primitive and widespread chemical messengers in the animal
and plant kingdoms. The evidence for purinergic signalling in plants, invertebrates and …

Despite identification of several cellular mechanisms being thought to underlie the
development of septic acute kidney injury (AKI), the pathophysiology of the occurrence of …

One of the most frequent and serious complications to develop in septic patients is acute
kidney injury (AKI), a disorder characterized by a rapid failure of the kidneys to adequately …

Highlights•P2X7 receptor is important in insulin secretion and responses of insulin sensitive
tissues.•Microvascular complications of diabetes involve P2X7 receptor.•Analysis of tissue …

The renal vasculature plays a major role in the regulation of renal blood flow and the ability
of the kidney to control the plasma volume and blood pressure. Renal vascular dysfunction …

The family of ligand-gated ion channels known as P2X receptors were discovered several
decades ago. Since the cloning of the seven P2X receptors (P2X1-P2X7), a huge research …