Poloxamer 188 as surfactant in biological formulations–An alternative for polysorbate 20/80?
L Bollenbach, J Buske, K Mäder, P Garidel - International Journal of …, 2022 - Elsevier
Surfactants are used to stabilize biologics. Particularly, polysorbates (Tween® 20 and
Tween® 80) dominate the group of surfactants in protein and especially antibody drug …
Tween® 80) dominate the group of surfactants in protein and especially antibody drug …
Sickle cell disease: advances in treatment
RV Gardner - Ochsner journal, 2018 - ochsnerjournal.org
Background: Sickle cell disease causes significant morbidity and mortality and affects the
economic and healthcare status of many countries. Yet historically, the disease has not had …
economic and healthcare status of many countries. Yet historically, the disease has not had …
A randomized, double-blinded, placebo-controlled multicenter trial of adenosine as an adjunct to reperfusion in the treatment of acute myocardial infarction (AMISTAD …
Objectives: The purpose of this research was to determine the effect of intravenous
adenosine on clinical outcomes and infarct size in ST-segment elevation myocardial …
adenosine on clinical outcomes and infarct size in ST-segment elevation myocardial …
Impact of right ventricular involvement on mortality and morbidity in patients with inferior myocardial infarction
SR Mehta, JW Eikelboom, MK Natarajan, R Diaz… - Journal of the American …, 2001 - jacc.org
OBJECTIVES We sought to evaluate the prognostic impact of right ventricular (RV)
myocardial involvement in patients with inferior myocardial infarction (MI). BACKGROUND …
myocardial involvement in patients with inferior myocardial infarction (MI). BACKGROUND …
Adenosine as an adjunct to thrombolytic therapy for acute myocardial infarction: results of a multicenter, randomized, placebo-controlled trial: the Acute Myocardial …
KW Mahaffey, JA Puma, NA Barbagelata… - Journal of the American …, 1999 - jacc.org
Abstract OBJECTIVES The Acute Myocardial Infarction STudy of ADenosine (AMISTAD) trial
was designed to test the hypothesis that adenosine as an adjunct to thrombolysis would …
was designed to test the hypothesis that adenosine as an adjunct to thrombolysis would …
The relationships of left ventricular ejection fraction, end-systolic volume index and infarct size to six-month mortality after hospital discharge following myocardial …
RJ Burns, RJ Gibbons, Q Yi, RS Roberts… - Journal of the American …, 2002 - jacc.org
Objectives: We sought to relate left ventricular ejection fraction (EF), end-systolic volume
index (ESVI) and infarct size (IS), as measured in a single randomized trial, to six-month …
index (ESVI) and infarct size (IS), as measured in a single randomized trial, to six-month …
The quantification of infarct size
RJ Gibbons, US Valeti, PA Araoz, AS Jaffe - Journal of the American …, 2004 - jacc.org
We sought to summarize the published evidence regarding the measurement of infarct size
by serum markers, technetium-99m sestamibi single-photon emission computed …
by serum markers, technetium-99m sestamibi single-photon emission computed …
The effect of blockade of the CD11/CD18 integrin receptor on infarct size in patients with acute myocardial infarction treated with direct angioplasty: the results of the …
Objectives: The purpose of this study was to determine whether Hu23F2G (LeukoArrest), an
antibody to the CD11/CD18 integrin receptors, would reduce infarct size in patients …
antibody to the CD11/CD18 integrin receptors, would reduce infarct size in patients …
Shifting the open-artery hypothesis downstream: the quest for optimal reperfusion
MT Roe, EM Ohman, ACP Maas… - Journal of the American …, 2001 - jacc.org
Successful reperfusion after acute myocardial infarction (MI) has traditionally been
considered to be restoration of epicardial patency, but increasing evidence suggests that …
considered to be restoration of epicardial patency, but increasing evidence suggests that …
Reperfusion injury in humans: a review of clinical trials on reperfusion injury inhibitory strategies
MT Dirksen, GJ Laarman, ML Simoons… - Cardiovascular …, 2007 - academic.oup.com
The principal therapy in patients with myocardial infarction to limit infarct size is myocardial
reperfusion by mechanical or pharmacological intervention. Reperfusion has been …
reperfusion by mechanical or pharmacological intervention. Reperfusion has been …