Astrocytes are highly complex cells with many emerging putative roles in brain function. Of
these, gliotransmission (active information transfer from glia to neurons) has probably the …

Alzheimer's disease (AD) is known as the most fatal chronic neurodegenerative disease in
adults along with progressive loss of memory and other cognitive function disorders. Cyclin …

Synaptic vesicle recycling has long served as a model for the general mechanisms of
cellular trafficking. We used an integrative approach, combining quantitative immunoblotting …

Neuronal communication crucially relies on exocytosis of neurotransmitters from synaptic
vesicles (SVs) which are clustered at synapses. To ensure reliable neurotransmitter release …

Synaptic vesicle recycling is one of the best‐studied cellular pathways. Many of the proteins
involved are known, and their interactions are becoming increasingly clear. However, as for …

Synaptic vesicles can be released at extremely high rates, which places an extraordinary
demand on the recycling machinery. Previous ultrastructural studies of vesicle recycling …

Ultrafast endocytosis generates vesicles from the plasma membrane as quickly as 50 ms in
hippocampal neurons following synaptic vesicle fusion. The molecular mechanism …

Despite the central role of amyloid β (Aβ) peptide in the etiopathogenesis of Alzheimer's
disease (AD), its physiological function in healthy brain is still debated. It is well established …

Synaptic communication in the nervous system is initiated by the fusion of synaptic vesicles
with the presynaptic plasma membrane and subsequent neurotransmitter release. In the …

In the healthy brain, neuronal excitability and synaptic strength are homeostatically
regulated to keep neuronal network activity within physiological boundaries. Epilepsy is …