[HTML][HTML] Mechanisms of autoantibody-induced pathology
RJ Ludwig, K Vanhoorelbeke, F Leypoldt… - Frontiers in …, 2017 - frontiersin.org
Autoantibodies are frequently observed in healthy individuals. In a minority of these
individuals, they lead to manifestation of autoimmune diseases, such as rheumatoid arthritis …
individuals, they lead to manifestation of autoimmune diseases, such as rheumatoid arthritis …
Mast cell function: a new vision of an old cell
EZM da Silva, MC Jamur… - Journal of Histochemistry …, 2014 - journals.sagepub.com
Since first described by Paul Ehrlich in 1878, mast cells have been mostly viewed as
effectors of allergy. It has been only in the past two decades that mast cells have gained …
effectors of allergy. It has been only in the past two decades that mast cells have gained …
[HTML][HTML] TNF leads to mtDNA release and cGAS/STING-dependent interferon responses that support inflammatory arthritis
J Willemsen, MT Neuhoff, T Hoyler, E Noir, C Tessier… - Cell reports, 2021 - cell.com
Tumor necrosis factor (TNF) is a key driver of several inflammatory diseases, such as
rheumatoid arthritis, inflammatory bowel disease, and psoriasis, in which affected tissues …
rheumatoid arthritis, inflammatory bowel disease, and psoriasis, in which affected tissues …
[HTML][HTML] RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL
RIPK3 and its substrate MLKL are essential for necroptosis, a lytic cell death proposed to
cause inflammation via the release of intracellular molecules. Whether and how RIPK3 …
cause inflammation via the release of intracellular molecules. Whether and how RIPK3 …
[HTML][HTML] Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling
SA Jones, J Scheller… - The Journal of clinical …, 2011 - Am Soc Clin Investig
The successful treatment of certain autoimmune conditions with the humanized anti–IL-6
receptor (IL-6R) antibody tocilizumab has emphasized the clinical importance of cytokines …
receptor (IL-6R) antibody tocilizumab has emphasized the clinical importance of cytokines …
Inflammasomes contributing to inflammation in arthritis
L Spel, F Martinon - Immunological reviews, 2020 - Wiley Online Library
Inflammasomes are intracellular multiprotein signaling platforms that initiate inflammatory
responses in response to pathogens and cellular damage. Active inflammasomes induce …
responses in response to pathogens and cellular damage. Active inflammasomes induce …
[HTML][HTML] IL-1β–driven osteoclastogenic Tregs accelerate bone erosion in arthritis
A Levescot, MH Chang, J Schnell… - The Journal of …, 2021 - Am Soc Clin Investig
IL-1β is a proinflammatory mediator with roles in innate and adaptive immunity. Here we
show that IL-1β contributes to autoimmune arthritis by inducing osteoclastogenic capacity in …
show that IL-1β contributes to autoimmune arthritis by inducing osteoclastogenic capacity in …
Identification of a key pathway required for the sterile inflammatory response triggered by dying cells
Dying cells stimulate inflammation, and this response is thought to contribute to the
pathogenesis of many diseases. Very little has been known, however, about how cell death …
pathogenesis of many diseases. Very little has been known, however, about how cell death …
Mitochondrial DNA and TLR9 drive muscle inflammation upon Opa1 deficiency
A Rodríguez‐Nuevo, A Díaz‐Ramos, E Noguera… - The EMBO …, 2018 - embopress.org
Opa1 participates in inner mitochondrial membrane fusion and cristae morphogenesis.
Here, we show that muscle‐specific Opa1 ablation causes reduced muscle fiber size …
Here, we show that muscle‐specific Opa1 ablation causes reduced muscle fiber size …
[HTML][HTML] The dual role of short fatty acid chains in the pathogenesis of autoimmune disease models
M Mizuno, D Noto, N Kaga, A Chiba, S Miyake - PloS one, 2017 - journals.plos.org
Autoimmune diseases are influenced by both genetic and environmental factors. The gut
environment has attracted much attention as an essential component that modulates …
environment has attracted much attention as an essential component that modulates …