The development of allergic disease involves the production of IgE antibodies upon allergen
exposure in a process called sensitization. IgE binds to receptors on the surface of mast …

The rise of antibodies as a promising and rapidly growing class of biotherapeutic proteins
has motivated numerous studies to characterize and understand antibody structures. In the …

Advances in structural biology and the exponential increase in the amount of high-quality
experimental structural data available in the Protein Data Bank has motivated numerous …

In the last decades, antibodies have emerged as one of the most important and successful
classes of biopharmaceuticals. The highest variability and diversity of an antibody is …

Characterizing and understanding the antibody binding interface have become a pre-
requisite for rational antibody design and engineering. The antigen-binding site is formed by …

A major challenge in the development of antibody biotherapeutics is their tendency to
aggregate. One root cause for aggregation is exposure of hydrophobic surface regions to …

In the past decade, the relevance of antibodies as therapeutics has increased substantially.
Therefore, structural and functional characterization, in particular of the complementarity …

Antibodies have emerged as one of the fastest growing classes of biotherapeutic proteins.
To improve the rational design of antibodies, we investigate the conformational diversity of …

T-cell receptors are an important part in the adaptive immune system as they are
responsible for detecting foreign proteins presented by the major histocompatibility complex …

Fab consist of a heavy and light chain and can be subdivided into a variable (VH and VL)
and a constant region (CH 1 and CL). The variable region contains the complementarity …