Human-induced pluripotent stem cell-derived cardiomyocytes, 3D cardiac structures, and heart-on-a-chip as tools for drug research
K Andrysiak, J Stępniewski, J Dulak - Pflügers Archiv-European Journal of …, 2021 - Springer
Abstract Development of new drugs is of high interest for the field of cardiac and
cardiovascular diseases, which are a dominant cause of death worldwide. Before being …
cardiovascular diseases, which are a dominant cause of death worldwide. Before being …
[HTML][HTML] A comprehensive overview of the complex world of the endo-and sarcoplasmic reticulum Ca2+-leak channels
FO Lemos, G Bultynck, JB Parys - … et Biophysica Acta (BBA)-Molecular Cell …, 2021 - Elsevier
Inside cells, the endoplasmic reticulum (ER) forms the largest Ca 2+ store. Ca 2+ is actively
pumped by the SERCA pumps in the ER, where intraluminal Ca 2+-binding proteins enable …
pumped by the SERCA pumps in the ER, where intraluminal Ca 2+-binding proteins enable …
hiPSCs derived cardiac cells for drug and toxicity screening and disease modeling: what micro-electrode-array analyses can tell us
S Kussauer, R David, H Lemcke - Cells, 2019 - mdpi.com
Human induced pluripotent stem cell (iPSC)-derived cardiomyocytes (CM) have been
intensively used in drug development and disease modeling. Since iPSC-cardiomyocyte …
intensively used in drug development and disease modeling. Since iPSC-cardiomyocyte …
A drug and ATP binding site in type 1 ryanodine receptor
The ryanodine receptor (RyR)/calcium release channel on the sarcoplasmic reticulum (SR)
is required for excitation-contraction coupling in skeletal and cardiac muscle. Inherited …
is required for excitation-contraction coupling in skeletal and cardiac muscle. Inherited …
Reprogramming: emerging strategies to rejuvenate aging cells and tissues
Q Alle, E Le Borgne, O Milhavet… - International journal of …, 2021 - mdpi.com
Aging is associated with a progressive and functional decline of all tissues and a striking
increase in many “age-related diseases”. Although aging has long been considered an …
increase in many “age-related diseases”. Although aging has long been considered an …
How does flecainide impact RyR2 channel function?
SC Salvage, CLH Huang, JA Fraser… - Journal of General …, 2022 - rupress.org
Flecainide, a cardiac class 1C blocker of the surface membrane sodium channel (NaV1. 5),
has also been reported to reduce cardiac ryanodine receptor (RyR2)-mediated …
has also been reported to reduce cardiac ryanodine receptor (RyR2)-mediated …
Personalized medicine in the dish to prevent calcium leak associated with short-coupled polymorphic ventricular tachycardia in patient-derived cardiomyocytes
Background Polymorphic ventricular tachycardia (PMVT) is a rare genetic disease
associated with structurally normal hearts which in 8% of cases can lead to sudden cardiac …
associated with structurally normal hearts which in 8% of cases can lead to sudden cardiac …
“Ryanopathies” and RyR2 dysfunctions: can we further decipher them using in vitro human disease models?
The regulation of intracellular calcium (Ca2+) homeostasis is fundamental to maintain
normal functions in many cell types. The ryanodine receptor (RyR), the largest intracellular …
normal functions in many cell types. The ryanodine receptor (RyR), the largest intracellular …
DMD Pluripotent Stem Cell Derived Cardiac Cells Recapitulate in vitro Human Cardiac Pathophysiology
S Jelinkova, A Vilotic, J Pribyl, F Aimond… - … in bioengineering and …, 2020 - frontiersin.org
Duchenne muscular dystrophy (DMD) is a severe genetic disorder characterized by the lack
of functional dystrophin. DMD is associated with progressive dilated cardiomyopathy …
of functional dystrophin. DMD is associated with progressive dilated cardiomyopathy …
Modeling polymorphic ventricular tachycardia at rest using patient-specific induced pluripotent stem cell-derived cardiomyocytes
Background While mutations in the cardiac type 2 ryanodine receptor (RyR2) have been
linked to exercise-induced or catecholaminergic polymorphic ventricular tachycardia …
linked to exercise-induced or catecholaminergic polymorphic ventricular tachycardia …