The dynorphin/κ-opioid receptor system and its role in psychiatric disorders
HA Tejeda, TS Shippenberg, R Henriksson - Cellular and Molecular Life …, 2012 - Springer
The dynorphin/κ-opioid receptor system has been implicated in the pathogenesis and
pathophysiology of several psychiatric disorders. In the present review, we present evidence …
pathophysiology of several psychiatric disorders. In the present review, we present evidence …
Endogenous opioid regulation of hippocampal function
ML Simmons, C Chavkin - International review of neurobiology, 1996 - Elsevier
Publisher Summary This chapter discusses the anatomy and physiology of opioids in the
hippocampus. It also discusses the roles of opioids in learning and memory processes and …
hippocampus. It also discusses the roles of opioids in learning and memory processes and …
Striatal fosB expression is causally linked with l-DOPA-induced abnormal involuntary movements and the associated upregulation of striatal prodynorphin mRNA in a …
M Andersson, A Hilbertson, MA Cenci - Neurobiology of disease, 1999 - Elsevier
Rats with unilateral dopamine-denervating lesions sustained a 3-week treatment with a daily
l-DOPA dose that is in the therapeutic range for Parkinson's disease. In most of the treated …
l-DOPA dose that is in the therapeutic range for Parkinson's disease. In most of the treated …
Inhibition of cAMP response element-binding protein or dynorphin in the nucleus accumbens produces an antidepressant-like effect
SS Newton, J Thome, TL Wallace… - Journal of …, 2002 - Soc Neuroscience
The cAMP response element-binding protein (CREB) is a critical integrator of neural
plasticity that is responsive in a brain region-specific manner to a variety of environmental …
plasticity that is responsive in a brain region-specific manner to a variety of environmental …
[HTML][HTML] Gene expression profiling of facilitated L-LTP in VP16-CREB mice reveals that BDNF is critical for the maintenance of LTP and its synaptic capture
Expression of VP16-CREB, a constitutively active form of CREB, in hippocampal neurons of
the CA1 region lowers the threshold for eliciting the late, persistent phase of long-term …
the CA1 region lowers the threshold for eliciting the late, persistent phase of long-term …
Neuronal adaptation to amphetamine and dopamine: molecular mechanisms of prodynorphin gene regulation in rat striatum
Induction of prodynorphin gene expression by psychostimulant drugs may represent a
compensatory adaptation to excessive dopamine stimulation and may contribute to the …
compensatory adaptation to excessive dopamine stimulation and may contribute to the …
Cocaine-induced intracellular signaling and gene expression are oppositely regulated by the dopamine D1 and D3 receptors
L Zhang, D Lou, H Jiao, D Zhang, X Wang… - Journal of …, 2004 - Soc Neuroscience
Repeated exposure to cocaine can induce neuroadaptations in the brain. One mechanism
by which persistent changes occur involves alterations in gene expression mediated by the …
by which persistent changes occur involves alterations in gene expression mediated by the …
Dual regulation of macrophage migration inhibitory factor (MIF) expression in hypoxia by CREB and HIF-1
Macrophage migration inhibitory factor (MIF) is a well-described pro-inflammatory mediator
that has also been implicated in the process of oncogenic transformation and tumor …
that has also been implicated in the process of oncogenic transformation and tumor …
cAMP response element-binding protein is required for dopamine-dependent gene expression in the intact but not the dopamine-denervated striatum
The cAMP response element-binding protein (CREB) is believed to play a pivotal role in
dopamine (DA) receptor-mediated nuclear signaling and neuroplasticity. Here we …
dopamine (DA) receptor-mediated nuclear signaling and neuroplasticity. Here we …
Calmodulin kinase II attenuation of gene transcription by preventing cAMP response element-binding protein (CREB) dimerization and binding of the CREB-binding …
X Wu, CT McMurray - Journal of Biological Chemistry, 2001 - ASBMB
Calmodulin Kinase II (CamKII) inhibits the transcription of many CRE-dependent genes, but
the mechanism of dominant transcriptional inhibition is unknown. Here we show that …
the mechanism of dominant transcriptional inhibition is unknown. Here we show that …