Mass spectrometry (MS) has become one of the key technologies of structural biology. In this
review, the contributions of chemical cross-linking combined with mass spectrometry (XL …

Complex mechanisms are in place to maintain genome stability. Ubiquitination of chromatin
plays a central role in these mechanisms. The ever-growing complexity of the ubiquitin (Ub) …

Mutations in the E3 ubiquitin ligase RING domains of BRCA1/BARD1 predispose carriers to
breast and ovarian cancers. We present the structure of the BRCA1/BARD1 RING …

Ubiquitination/ubiquitylation, one of the most fundamental post-translational modifications,
regulates almost every critical cellular process in eukaryotes. Emerging evidence has shown …

Abstract Polycomb repressive complex 1 (PRC1) is an essential chromatin-modifying
complex that monoubiquitinates histone H2A and is involved in maintaining the repressed …

Modulation of chromatin templates in response to cellular cues, including DNA damage,
relies heavily on the post-translation modification of histones. Numerous types of histone …

The development of methyl-transverse relaxation-optimized spectroscopy (methyl-TROSY)–
based NMR methods, in concert with robust strategies for incorporation of methyl-group …

Mass spectrometry-based proteomics provides a holistic snapshot of the entire protein set of
living cells on a molecular level. Currently, only a few deep learning approaches exist that …

Structures of biomolecular systems are increasingly computed by integrative modeling. In
this approach, a structural model is constructed by combining information from multiple …

Inhibition of host DNA damage response (DDR) is a common mechanism used by viruses to
manipulate host cellular machinery and orchestrate viral life cycles. Epstein-Barr virus …