Iron is essential to virtually all organisms, but poses problems of toxicity and poor solubility.
Bacteria have evolved various mechanisms to counter the problems imposed by their iron …

Tuberculosis (TB), one of the oldest known human diseases. is still is one of the major
causes of mortality, since two million people die each year from this malady. TB has many …

▪ Abstract The ability of pathogens to obtain iron from transferrins, ferritin, hemoglobin, and
other iron-containing proteins of their host is central to whether they live or die. To combat …

The appearance of oxygen on earth led to two major problems: the production of potentially
deleterious reactive oxygen species and a drastic decrease in iron availability. In addition …

The bacteriostatic and bactericidal effects and the transcriptional response of
Mycobacterium tuberculosis to representative oxidative and nitrosative stresses were …

Mycobacterium tuberculosis is a facultative intracellular pathogen that thrives inside host
macrophages. A key trait of M. tuberculosis is to exploit and manipulate metal cation …

Iron is both an essential nutrient for the growth of microorganisms, as well as a dangerous
metal due to its capacity to generate reactive oxygen species (ROS) via the Fenton reaction …

The mycobacterial IdeR protein is a metal-dependent regulator of the DtxR (diphtheria toxin
repressor) family. In the presence of iron, it binds to a specific DNA sequence in the …

Bacteria commonly utilise a unique type of transporter, called Feo, to specifically acquire the
ferrous (Fe 2+) form of iron from their environment. Enterobacterial Feo systems are …

Fur (ferric uptake regulator) proteins control iron uptake in many Gram‐negative bacteria.
Although Fur homologues have been identified in Gram‐positive bacteria, their roles in gene …