Since the discovery of sickle cell disease (SCD) in 1910, enormous strides have been made
in the elucidation of the pathogenesis of its protean complications, which has inspired recent …

Hemolysis is a fundamental feature of sickle cell anemia that contributes to its
pathophysiology and phenotypic variability. Decompartmentalized hemoglobin, arginase 1 …

Background Zinc is a trace element with potent immunoregulatory and antiviral properties,
and is utilized in the treatment of coronavirus disease 2019 (COVID-19). However, we do not …

Background—Intravascular red cell hemolysis impairs nitric oxide (NO)–redox homeostasis,
producing endothelial dysfunction, platelet activation, and vasculopathy. Red blood cell …

Sickle cell disease (SCD) is a single gene disorder causing a debilitating systemic
syndrome characterised by chronic anaemia, acute painful episodes, organ infarction and …

Hemolysis, long discounted as a critical measure of sickle cell disease severity when
compared with sickle vaso-occlusion, may be the proximate cause of some disease …

Sickle cell disease (SCD) is a pleiotropic genetic disorder of hemoglobin that has profound
multiorgan effects. The low prevalence of SCD (∼ 100,000/US) has limited progress in …

The aim of this prospective study was to evaluate the long-term efficacy and safety of
hydroxyurea (HU) in patients with sickle cell disease (SCD). Thirty-four patients with sickle …

Introduction Priapism describes a persistent erection arising from dysfunction of
mechanisms regulating penile tumescence, rigidity, and flaccidity. A correct diagnosis of …

Hydroxyurea, a myelosuppressive agent, is the only effective drug proven to reduce the
frequency of painful episodes. It raises the level of HbF and the haemoglobin level. It usually …