Spinal cord injury (SCI) leads to loss of motor and sensory function below the injury level
and imposes a considerable burden on patients, families, and society. Repair of the injured …

Spinal cord injury (SCI) is a devastating neurological disorder that affects thousands of
individuals each year. Over the past decades an enormous progress has been made in our …

We tested the feasibility and safety of human-spinal-cord-derived neural stem cell (NSI-566)
transplantation for the treatment of chronic spinal cord injury (SCI). In this clinical trial, four …

Spinal cord injury (SCI) can lead to paraplegia or quadriplegia. Although there are no fully
restorative treatments for SCI, various rehabilitative, cellular and molecular therapies have …

Failure of axon regeneration after central nervous system (CNS) injuries results in
permanent functional deficits. Numerous studies in the past suggested that blocking …

The Rho signaling pathway regulates the cytoskeleton and motility and plays an important
role in neuronal growth inhibition. Here we demonstrate that inactivation of Rho or its …

This review considers the 2 sources of neurotrophic factors in the peripheral nervous system
(PNS), the neurons and the nonneuronal cells in the denervated distal nerve stumps, and …

Abstract Background/Objective: Olfactory mucosa is a readily accessible source of olfactory
ensheathing and stem-like progenitor cells for neural repair. To determine the safety and …

Contusive spinal cord injury (SCI) results in the formation of a chronic lesion cavity
surrounded by a rim of spared fibers. Tissue bridges containing axons extend from the …

The failure of axons to regenerate after spinal cord injury remains one of the greatest
challenges facing both medicine and neuroscience, but in the last 20 years there have been …