Major depressive disorder (MDD), which is a leading psychiatric illness across the world,
severely affects quality of life and causes an increased incidence of suicide. Evidence from …

This paper describes the effects of immune genes genetic variants and mRNA expression
on depression's risk, severity, and response to antidepressant treatment, through a …

Instrumental variables have been widely used for estimating the causal effect between
exposure and outcome. Conventional estimation methods require complete knowledge …

There is increasing evidence of prodromal manifestation of neuropsychiatric symptoms in a
variety of neurodegenerative diseases such as Parkinson's disease (PD) and Huntington's …

A major challenge in instrumental variable (IV) analysis is to find instruments that are valid,
or have no direct effect on the outcome and are ignorable. Typically one is unsure whether …

Purpose Nowadays, the role of two tightly interconnected systems, the inflammatory
response system (IRS) and the compensatory immune response system (CIRS) in …

Depression is a worldwide illness with a significant impact on both family and society.
Conventional antidepressants are ineffective for more than 30% of patients. In such patients …

Background Identifying and characterizing how mixtures of exposures are associated with
health endpoints is challenging. We demonstrate how classification and regression trees …

The A1 allele of the DRD2/ANKK1 Taq1A polymorphism (rs1800497) is associated with
reduced striatal D2/3 receptor binding in healthy individuals (Con) as well as depression …

The classification of interleukin-6 (IL-6) as a pro-inflammatory cytokine undervalues the
biological impact of this cytokine in health and disease. With broad activities affecting the …