Mitochondria as a cellular hub in infection and inflammation
Mitochondria are the energy center of the cell. They are found in the cell cytoplasm as
dynamic networks where they adapt energy production based on the cell's needs. They are …
dynamic networks where they adapt energy production based on the cell's needs. They are …
Pathology and pathogenesis of Chagas heart disease
KM Bonney, DJ Luthringer, SA Kim… - Annual Review of …, 2019 - annualreviews.org
Chagas heart disease is an inflammatory cardiomyopathy that develops in approximately
one-third of people infected with the protozoan parasite Trypanosoma cruzi. One way T …
one-third of people infected with the protozoan parasite Trypanosoma cruzi. One way T …
Current understanding of immunity to Trypanosoma cruzi infection and pathogenesis of Chagas disease
Chagas disease caused by Trypanosoma cruzi remains an important neglected tropical
disease and a cause of significant morbidity and mortality. No longer confined to endemic …
disease and a cause of significant morbidity and mortality. No longer confined to endemic …
The role of reactive-oxygen-species in microbial persistence and inflammation
R Spooner, Ö Yilmaz - International journal of molecular sciences, 2011 - mdpi.com
The mechanisms of chronic infections caused by opportunistic pathogens are of keen
interest to both researchers and health professionals globally. Typically, chronic infectious …
interest to both researchers and health professionals globally. Typically, chronic infectious …
Oxidative stress fuels Trypanosoma cruzi infection in mice
Oxidative damage contributes to microbe elimination during macrophage respiratory burst.
Nuclear factor, erythroid-derived 2, like 2 (NRF2) orchestrates antioxidant defenses …
Nuclear factor, erythroid-derived 2, like 2 (NRF2) orchestrates antioxidant defenses …
[HTML][HTML] Signaling mechanism of poly (ADP-ribose) polymerase-1 (PARP-1) in inflammatory diseases
X Ba, NJ Garg - The American journal of pathology, 2011 - Elsevier
Poly (ADP-ribosyl) ation, attaching the ADP-ribose polymer chain to the receptor protein, is a
unique posttranslational modification. Poly (ADP-ribose) polymerase-1 (PARP-1) is a well …
unique posttranslational modification. Poly (ADP-ribose) polymerase-1 (PARP-1) is a well …
Glycyrrhiza glabra (Licorice) root extract attenuates doxorubicin-induced cardiotoxicity via alleviating oxidative stress and stabilising the cardiac health in H9c2 …
Ethnopharmacological relevance Doxorubicin (DOX) is an effective anti-neoplastic drug,
however; it has downside effects on cardiac health and other vital organs. The herbal …
however; it has downside effects on cardiac health and other vital organs. The herbal …
[HTML][HTML] Immunity and vaccine development efforts against Trypanosoma cruzi
Trypanosoma cruzi (T. cruzi) is the causative agent for Chagas disease (CD). There is a
critical lack of methods for prevention of infection or treatment of acute infection and chronic …
critical lack of methods for prevention of infection or treatment of acute infection and chronic …
Co-exposure of cardiomyocytes to IFN-γ and TNF-α induces mitochondrial dysfunction and nitro-oxidative stress: implications for the pathogenesis of chronic chagas …
JPS Nunes, P Andrieux, P Brochet… - Frontiers in …, 2021 - frontiersin.org
Infection by the protozoan Trypanosoma cruzi causes Chagas disease cardiomyopathy
(CCC) and can lead to arrhythmia, heart failure and death. Chagas disease affects 8 million …
(CCC) and can lead to arrhythmia, heart failure and death. Chagas disease affects 8 million …
Trypanosoma cruzi Antioxidant Enzymes As Virulence Factors in Chagas Disease
L Piacenza, G Peluffo, MN Alvarez… - Antioxidants & Redox …, 2013 - liebertpub.com
Significance: Chagas disease (CD) affects several million people in Latin America and is
spreading beyond its classical boundaries due to the migration of infected host and insect …
spreading beyond its classical boundaries due to the migration of infected host and insect …