Oncogenic signalling and metabolic alterations are interrelated in cancer cells. mTOR,
which is frequently activated in cancer, controls cell growth and metabolism. mTOR …

Metformin is a well-known anti-diabetic drug that has been repurposed for several emerging
applications, including as an anti-cancer agent. It boasts the distinct advantages of an …

Mitochondria are recognized as one of the most important targets for new drug design in
cancer, cardiovascular, and neurological diseases. Currently, the most effective way to …

Awareness that the metabolic phenotype of cells within tumours is heterogeneous—and
distinct from that of their normal counterparts—is growing. In general, tumour cells …

Background: Our previous study demonstrated that metabolic inflammation exacerbates
dopaminergic neuronal degeneration in type 2 diabetes mice. Metformin, a typical oral …

Bladder cancer—the tenth most frequent cancer worldwide—has a heterogeneous natural
history and clinical behaviour. The predominant histological subtype, urothelial bladder …

Given the role of mitochondria in oxygen consumption, metabolism and cell death
regulation, alterations in mitochondrial function or dysregulation of cell death pathways …

Cancer metabolism is emerging as a chemotherapeutic target. Enhanced glycolysis and
suppression of mitochondrial metabolism characterize the Warburg phenotype in cancer …

Introduction Cellular metabolism is altered during cancer initiation and progression, which
allows cancer cells to increase anabolic synthesis, avoid apoptosis and adapt to low nutrient …

Metformin, a synthetic biguanide, is currently one of the most frequently recommended
medications for type 2 diabetes treatment around the world. This review presents the latest …