mTOR signalling and cellular metabolism are mutual determinants in cancer
Oncogenic signalling and metabolic alterations are interrelated in cancer cells. mTOR,
which is frequently activated in cancer, controls cell growth and metabolism. mTOR …
which is frequently activated in cancer, controls cell growth and metabolism. mTOR …
Metformin and cancer hallmarks: shedding new lights on therapeutic repurposing
Y Hua, Y Zheng, Y Yao, R Jia, S Ge… - Journal of Translational …, 2023 - Springer
Metformin is a well-known anti-diabetic drug that has been repurposed for several emerging
applications, including as an anti-cancer agent. It boasts the distinct advantages of an …
applications, including as an anti-cancer agent. It boasts the distinct advantages of an …
Mitochondria-targeted triphenylphosphonium-based compounds: syntheses, mechanisms of action, and therapeutic and diagnostic applications
Mitochondria are recognized as one of the most important targets for new drug design in
cancer, cardiovascular, and neurological diseases. Currently, the most effective way to …
cancer, cardiovascular, and neurological diseases. Currently, the most effective way to …
Cancer metabolism: a therapeutic perspective
UE Martinez-Outschoorn, M Peiris-Pagés… - Nature reviews Clinical …, 2017 - nature.com
Awareness that the metabolic phenotype of cells within tumours is heterogeneous—and
distinct from that of their normal counterparts—is growing. In general, tumour cells …
distinct from that of their normal counterparts—is growing. In general, tumour cells …
Metformin prevents dopaminergic neuron death in MPTP/P-induced mouse model of Parkinson's disease via autophagy and mitochondrial ROS clearance
M Lu, C Su, C Qiao, Y Bian, J Ding… - International Journal of …, 2016 - academic.oup.com
Background: Our previous study demonstrated that metabolic inflammation exacerbates
dopaminergic neuronal degeneration in type 2 diabetes mice. Metformin, a typical oral …
dopaminergic neuronal degeneration in type 2 diabetes mice. Metformin, a typical oral …
Competitive glucose metabolism as a target to boost bladder cancer immunotherapy
J Afonso, LL Santos, A Longatto-Filho… - Nature Reviews …, 2020 - nature.com
Bladder cancer—the tenth most frequent cancer worldwide—has a heterogeneous natural
history and clinical behaviour. The predominant histological subtype, urothelial bladder …
history and clinical behaviour. The predominant histological subtype, urothelial bladder …
Mitochondria, cholesterol and cancer cell metabolism
V Ribas, C García-Ruiz… - Clinical and translational …, 2016 - Springer
Given the role of mitochondria in oxygen consumption, metabolism and cell death
regulation, alterations in mitochondrial function or dysregulation of cell death pathways …
regulation, alterations in mitochondrial function or dysregulation of cell death pathways …
VDAC regulation: a mitochondrial target to stop cell proliferation
D Fang, EN Maldonado - Advances in cancer research, 2018 - Elsevier
Cancer metabolism is emerging as a chemotherapeutic target. Enhanced glycolysis and
suppression of mitochondrial metabolism characterize the Warburg phenotype in cancer …
suppression of mitochondrial metabolism characterize the Warburg phenotype in cancer …
Monitoring cancer prognosis, diagnosis and treatment efficacy using metabolomics and lipidomics
EG Armitage, AD Southam - Metabolomics, 2016 - Springer
Introduction Cellular metabolism is altered during cancer initiation and progression, which
allows cancer cells to increase anabolic synthesis, avoid apoptosis and adapt to low nutrient …
allows cancer cells to increase anabolic synthesis, avoid apoptosis and adapt to low nutrient …
Is metformin a perfect drug? Updates in pharmacokinetics and pharmacodynamics
M Markowicz-Piasecka, KM Huttunen… - Current …, 2017 - ingentaconnect.com
Metformin, a synthetic biguanide, is currently one of the most frequently recommended
medications for type 2 diabetes treatment around the world. This review presents the latest …
medications for type 2 diabetes treatment around the world. This review presents the latest …