Over the last 30 years, the 18-kDa TSPO protein has been considered as the PET imaging
biomarker of reference to measure increased neuroinflammation. Generally assumed to …

Pyrazolo [1, 5-a] pyrimidines are the dominant motif of many drugs; for instance, zaleplon
and indiplon are sedative agents and ocinaplon was identified as an anxiolytic agent. The …

Alzheimer's disease (AD) is mainly characterized by the deposition of extracellular amyloid
plaques and intracellular accumulation of neurofibrillary tangles (NFTs). While the recent …

Hypoxia, a deficiency in the levels of oxygen, is a common feature of most solid tumors and
induces many characteristics of cancer. Hypoxia is associated with metastases and strong …

C–F bond formation is an important research topic in organic synthesis because of the wide
use of organofluorine compounds in various areas including pharmaceuticals, agricultural …

The development of novel PET imaging agents that selectively bind specific dementia-
related targets can contribute significantly to accurate, differential and early diagnosis of …

[11C] ER176 has adequate sensitivity to image the human brain translocator protein (TSPO)
in all three genotypes by positron emission tomography (PET). However, its clinical …

Positron emission tomography (PET) is a noninvasive molecular imaging method
extensively applied in the detection and treatment of various diseases. Hypoxia is a common …

Astrogliosis is a crucial feature of neuroinflammation and is characterized by the significant
upregulation of glial fibrillary acidic protein (GFAP) expression. Hence, visualizing GFAP in …

Translocator protein (TSPO) expression is closely related with neuroinflammation and
neuronal damage which might cause several central nervous system diseases. Herein, a …