Temporomandibular disorders (TMD) are a group of diseases in the oral and maxillofacial
region that can manifest as acute or chronic persistent pain, affecting millions of people …

Chronic pain in temporomandibular disorder (TMD) is a common health problem.
Cumulating evidence indicates that the etiology of TMD pain is complex with multifactorial …

Brain inflammation develops with increased colitis. Pu-erh tea is considered a potential
dietary intervention to improve colitis. However, it's unclear whether Pu-erh tea helps …

Chronic craniofacial pain is intractable and its mechanisms remain unclarified. The rostral
ventromedial medulla (RVM) plays a crucial role in descending pain facilitation and …

Background The serotonin receptor 2A (HTR2A) has been described as an important
facilitation mediator of spinal nociceptive processing leading to central sensitization (CS) in …

Knee osteoarthritis (KOA) is a highly prevalent, chronic joint disorder, and it is a typical
disease which can develop chronic pain. Our previous study has proved that …

Background Dental treatment associated with unadaptable occlusal alteration can cause
chronic primary myofascial orofacial pain. The serotonin (5-HT) pathway from the rostral …

Chronic primary pain (CPP) occurs in the absence of tissue injury and includes
temporomandibular disorders (TMD), fibromyalgia syndrome (FMS) and irritable bowel …

Chronic primary pain, characterized by overlapping symptoms of chronic pain, anxiety, and
depression, is strongly associated with stress and is particularly prevalent among females …

Aims Fibromyalgia patients might experience temporomandibular disorder (TMD) as a
comorbidity. However, the connection between these two syndromes is not fully understood …