Chemotherapeutics occupy a pivotal role in the medication of different types of cancers, but
the prevalence and mortality rates of cancer remain high. The drug resistance and low …

The emergence of drug resistance has created unmet medical need for the development of
new classes of antibiotics. Innovation of new antibacterial agents with new mode of action …

Pim-1 kinase targeted recently has proved an essential goal of breast cancer therapy. We
report the design, synthesis with full characterization analysis of pyrazolo [3, 4-b] pyridine …

Liver cancer is the most common type of cancer in many countries. New studies and
statistics show rising liver cancer worldwide, so it is essential to seek new agents for this …

Pyrazolopyrimidine scaffold is one of the privileged heterocycles in drug discovery. This
scaffold produced numerous biological activities in which anticancer is important one …

Amino-4, 6-dimethylpyrazolopyridine was applied as a precursor for the synthesis of some
new pyridopyrazolo-triazine and pyridopyrazolo-triazole derivatives through diazotization …

A novel series of pyrido [2, 3-d] pyrimidines; pyrido [3, 2-e][1, 3, 4] triazolo; and tetrazolo [1, 5-
c] pyrimidines were synthesized via different chemical transformations starting from pyrazolo …

2-((3-Cyano-4, 6-dimethylpyridin-2-yl) oxy) acetohydrazide 1 was used as the precursor for
the synthesis of 5-thioxo-1, 3, 4-oxadiazol-2-yl) methoxy) nicotinonitrile 2. The latter was …

Colorectal cancer (CRC) is the third most common cancer globally, with high mortality.
Metastatic CRC is incurable in most cases, and multiple drug therapy can increase patients' …

The development and spread of resistance of human pathogenic bacteria to the action of
commonly used antibacterial drugs is one of the key problems in modern medicine. One of …