Purpose Radiation-induced lymphopenia (RIL) is the result of direct toxicity to circulating
lymphocytes as they traverse the irradiated field, occurs in 40% to 70% of patients who …

Simple Summary Cancer is multifaceted and consists of more than just a collection of
mutated cells. These cancerous cells reside along with other non-mutated cells in an …

Immune checkpoint inhibition (ICI) immunotherapy has revolutionized the approach to
metastatic non-small-cell lung cancer (NSCLC). In particular, antibodies blocking the …

In addition to inducing lethal DNA damage in tumor and stromal cells, radiation can alter the
interactions of tumor cells with their microenvironment. Recent technological advances in …

Purpose Radiation therapy (RT) induces an immune response, but the relationship of this
response with tumor type is not fully understood. This meta-analysis further elucidated this …

Recent clinical breakthroughs in cancer immunotherapy, especially with immune checkpoint
blockade, offer great hope for cancer sufferers–and have greatly changed the landscape of …

Periodontitis is prevalent in half of the adult population and raises critical health concerns as
it has been recently associated with an increased risk of cancer. While information about the …

Purpose Despite the strong interest in combining stereotactic ablative radiation therapy
(SAR) with immunotherapy, limited data characterizing the systemic immune response after …

Over the last several decades, a number of new treatment options for patients with
hepatocellular carcinoma (HCC) have been developed. While treatment decisions for some …

Cancer is a worldwide problem that threatens human health. Radiotherapy plays an
important role in a variety of cancer treatment methods. The administration of radiotherapy …