Pain is a major comorbidity of sickle cell disease (SCD). Patients with SCD may suffer from
both acute and chronic pain. Acute pain is caused by recurrent and unpredictable episodes …

SCD pain involves neuroimmune and neurovascular interactions. Such interactions have
pronociceptive impacts and impart therapy resistance. Elucidating molecular and cellular …

Acute pain serves as a protective mechanism, guiding the organism away from actual or
potential tissue injury. In contrast, chronic pain is a debilitating condition without any obvious …

Genetic risk factors for chronic postsurgical pain in adults have been established, but little is
known whether the same associations exist in children. It is even less clear how much …

Sickle cell disease (SCD) is characterized by hemolysis, inflammation, and pain.
Mechanisms of pain manifestation are complex, and there is a major gap in knowledge of …

Debilitating pain affects the lives of patients with sickle cell disease (SCD). Current pain
treatment for patients with SCD fail to completely resolve acute or chronic SCD pain …

The transcriptional response to cellular stress relies upon trafficking of regulators of
transcription between the nuclear and cytoplasmic compartments, which occurs through …

D-4F, ein ApoA-I-mimetisches Peptid, lindert mechanische Hyperalgesie nach
Verabreichung an Nagetiere, die an entzündlichen und neuropathischen Schmerzen leiden …

New chronic pain therapeutics are desperately needed, as many current treatments do not
adequately treat pain in many patients. Ongoing preclinical research has found promising …