Bone metabolism is a lifelong process that includes bone formation and resorption.
Osteoblasts and osteoclasts are the predominant cell types associated with bone …

Osteoarthritis (OA) is a disease which results in degeneration of cartilage within joints and
affects approximately 13.6% of adults over 20 years of age in Canada and the United States …

Despite the diverse roles of tripartite motif (Trim)-containing proteins in the regulation of
autophagy, the innate immune response, and cell differentiation, their roles in skeletal …

The G-protein coupled receptors (GPCRs) activated by free fatty acids (FFAs) have emerged
as new and exciting drug targets, due to their plausible translation from pharmacology to …

An aging world population exposed to a sedentary life style is currently plagued by chronic
metabolic diseases, such as type-2 diabetes, that are spreading worldwide at an …

Osteoarthritis (OA) is a degenerative joint disease affecting millions of people worldwide. In
OA, chondrocytes, synovial cells and other joint cells become activated when exposed to an …

The interplay between immune cells/macrophages and fibroblast‐like synoviocytes (FLSs)
plays a pivotal role in initiating synovitis; however, their involvement in metabolic disorders …

Fatty acid metabolism contributes to energy supply and plays an important role in regulating
immunity. Free fatty acids (FFAs) bind to free fatty acid receptors (FFARs) on the cell surface …

It is well known that free fatty acids (FFAs) have beneficial effects on the skeletal system,
however, which fatty acid sensing GPCR (s) and how the GPCR (s) regulating cartilage …

Osteoarthritis (OA) is a disease caused by joint degeneration with massive cartilage loss,
and obesity is among the risk factors for its onset, though the pathophysiological …