Highlights•Pseudomonas aeruginosa causes acute and chronic infections in
humans.•Virulence factors are co-regulated with lifestyles.•The Gac/Rsm cascade regulates …

Pseudomonas aeruginosa is a versatile opportunistic pathogen capable of infecting a broad
range of hosts, in addition to thriving in a broad range of environmental conditions outside of …

In many bacteria, the biofilm-promoting second messenger c-di-GMP is produced and
degraded by multiple diguanylate cyclases (DGC) and phosphodiesterases (PDE) …

Biofilm-based infections pose a serious threat to public health. Biofilms are surface-attached
communities of microorganisms, most commonly bacteria and yeast, residing in an …

Bacteria depend on two-component systems to detect and respond to threats. Simple
pathways comprise a single sensor kinase (SK) that detects a signal and activates a …

The cyclic di-GMP (c-di-GMP) second messenger represents a signaling system that
regulates many bacterial behaviors and is of key importance for driving the lifestyle switch …

Pseudomonas aeruginosa is an opportunistic human pathogen and is the primary cause of
nosocomial infections. Biofilm formation by this organism results in chronic and hard to …

Type IV pili are expressed by a wide range of prokaryotes, including the opportunistic
pathogen Pseudomonas aeruginosa. These flexible fibres mediate twitching motility, biofilm …

Chronic infections caused by Pseudomonas aeruginosa have been a major concern as their
spread and mortality continue to be on the rise. These infections are majorly attributed to …

Bacteria and many non-metazoan Eukaryotes respond to stresses and threats using two-
component systems (TCSs) comprising sensor kinases (SKs) and response regulators …