Rolling circle replication (RCR), including rolling circle amplification (RCA) and rolling circle
transcription (RCT), is an isothermal enzymatic reaction. Because of its high amplification …

Rolling circle amplification (RCA) is an efficient enzymatic isothermal reaction that using
circular probe as a template to generate long tandem single-stranded DNA or RNA products …

Circle-to-circle amplification (C2CA) is a specific and precise cascade nucleic acid
amplification method consisting of more than one round of padlock probe ligation and rolling …

MicroRNAs (miRNAs) detection with high specificity and sensitivity received abundant
attention because miRNAs have been reported to play a vital role in pathological …

Nucleic acid nanomaterials with good biocompatibility, biodegradability, and
programmability have important applications in biomedical field. Nucleic acid nanomaterials …

False-positive results cause a major problem in nucleic acid amplification, and require
external blank/negative controls for every test. However, external controls usually have a …

MicroRNAs are potential biomarkers for human cancers and other diseases due to their
roles as post-transcriptional regulators for gene expression. However, the detection of …

In comparison to alternative nanomaterials, magnetic micron/nano-sized particles show
unique advantages, eg, easy manipulation, stable signal, and high contrast. By applying …

MicroRNAs (miRNAs) are a family of conserved small noncoding RNAs whose expression is
associated with many diseases, including cancer. Salivary miRNAs are gaining popularity …

Infectious diseases are an enormous public health burden and a growing threat to human
health worldwide. Emerging or classic recurrent pathogens, or pathogens with resistant …