Traumatic brain injury (TBI) is one of the most common diseases in the central nervous
system (CNS) with high mortality and morbidity. Patients with TBI usually suffer many …

Alzheimer's disease (AD) is a progressive neurodegenerative disease and accounts for
most cases of dementia. The prevalence of AD has increased in the current rapidly aging …

Human brain structure changes throughout the lifespan. Altered brain growth or rates of
decline are implicated in a vast range of psychiatric, developmental and neurodegenerative …

Alzheimer's disease (AD) is an incurable neurodegenerative disease. Numerous studies
have demonstrated a critical role for dysregulated glucose metabolism in its pathogenesis …

APOE and Trem2 are major genetic risk factors for Alzheimer's disease (AD), but how they
affect microglia response to Aβ remains unclear. Here we report an APOE isoform-specific …

Damage or loss of brain cells and impaired neurochemistry, neurogenesis, and synaptic and
nonsynaptic plasticity of the brain lead to dementia in neurodegenerative diseases, such as …

Microglia are specialized dynamic immune cells in the central nervous system (CNS) that
plays a crucial role in brain homeostasis and in disease states. Persistent …

Aging is a complex biological process that increases the risk of age-related cognitive
degenerative diseases such as dementia, including Alzheimer's disease (AD), Lewy Body …

Triggering receptor expressed on myeloid cells 2 (TREM2) is a receptor mainly expressed
on the surface of microglia. It mediates multiple pathophysiological processes in various …

The concept of insulin resistance has been around since a few decades after the discovery
of insulin itself. To allude to the classic Charles Dicken's novel published 62 years before the …