The COVID-19 puzzle: deciphering pathophysiology and phenotypes of a new disease entity

MF Osuchowski, MS Winkler, T Skirecki… - The Lancet …, 2021 - thelancet.com
The zoonotic SARS-CoV-2 virus that causes COVID-19 continues to spread worldwide, with
devastating consequences. While the medical community has gained insight into the …

Pathophysiology of acute respiratory distress syndrome and COVID-19 lung injury

KE Swenson, ER Swenson - Critical care clinics, 2021 - criticalcare.theclinics.com
Acute respiratory distress syndrome (ARDS) is a complex syndrome of acute lung injury
leading to noncardiogenic pulmonary edema from many causes that is heterogenous in its …

Early outcomes after lung transplantation for severe COVID-19: a series of the first consecutive cases from four countries

A Bharat, TN Machuca, M Querrey… - The Lancet …, 2021 - thelancet.com
Background Lung transplantation is a life-saving treatment for patients with end-stage lung
disease; however, it is infrequently considered for patients with acute respiratory distress …

[HTML][HTML] Clinical characteristics and outcomes of invasively ventilated patients with COVID-19 in Argentina (SATICOVID): a prospective, multicentre cohort study

E Estenssoro, CI Loudet, FG Ríos, VSK Edul… - The Lancet …, 2021 - thelancet.com
Background Although COVID-19 has greatly affected many low-income and middle-income
countries, detailed information about patients admitted to the intensive care unit (ICU) is still …

[HTML][HTML] Mechanical ventilation parameters in critically ill COVID-19 patients: a scoping review

G Grasselli, E Cattaneo, G Florio, M Ippolito, A Zanella… - Critical Care, 2021 - Springer
Background The mortality of critically ill patients with COVID-19 is high, particularly among
those receiving mechanical ventilation (MV). Despite the high number of patients treated …

Longitudinal respiratory subphenotypes in patients with COVID-19-related acute respiratory distress syndrome: results from three observational cohorts

LDJ Bos, M Sjoding, P Sinha, SV Bhavani… - The lancet Respiratory …, 2021 - thelancet.com
Background Patients with COVID-19-related acute respiratory distress syndrome (ARDS)
have been postulated to present with distinct respiratory subphenotypes. However, most …

[HTML][HTML] Psychological distress and health-related quality of life in patients after hospitalization during the COVID-19 pandemic: A single-center, observational study

JH Vlake, S Wesselius, ME van Genderen… - PloS one, 2021 - journals.plos.org
Introduction Illnesses requiring hospitalization are known to negatively impact psychological
well-being and health-related quality of life (HRQoL) after discharge. The impact of …

[HTML][HTML] Integrative respiratory follow-up of severe COVID-19 reveals common functional and lung imaging sequelae

A Froidure, A Mahsouli, G Liistro, J De Greef… - Respiratory …, 2021 - Elsevier
Background COVID-19 pandemic resulted in an unprecedented number of hospitalizations
in general wards and intensive care units (ICU). Severe and critical COVID-19 patients suffer …

[HTML][HTML] Clinical features and prognostic factors in Covid-19: a prospective cohort study

S de Bruin, LD Bos, MA van Roon, AM Tuip-de Boer… - …, 2021 - thelancet.com
Background Mortality rates are high among hospitalized patients with COVID-19, especially
in those intubated on the ICU. Insight in pathways associated with unfavourable outcome …

[HTML][HTML] Different methods to improve the monitoring of noninvasive respiratory support of patients with severe pneumonia/ARDS due to COVID-19: an update

P Pelosi, R Tonelli, C Torregiani, E Baratella… - Journal of Clinical …, 2022 - mdpi.com
The latest guidelines for the hospital care of patients affected by coronavirus disease 2019
(COVID-19)-related acute respiratory failure have moved towards the widely accepted use of …