The field of polymeric nanoparticles is quickly expanding and playing a pivotal role in a wide
spectrum of areas ranging from electronics, photonics, conducting materials, and sensors to …

Low drug bioavailability, which is mostly a result of poor aqueous drug solubilities and of
inadequate drug dissolution rates, is one of the most significant challenges that …

Supercritical carbon dioxide (SC‐CO2) is CO2 that is stored beyond its critical point of 7.4
MPa and 31.1° C. Given the request for consumption of a green solvent for the environment …

The poor solubility of significant number of Active Pharmaceutical Ingredients (APIs) has
become a major challenge in the drug development process. Drugs with poor solubility are …

Due to the fascinating properties of low viscosity, zero surface tension, high gas-like
diffusivity and high liquid-like density, as well as the characteristics of nontoxic …

The use of drug nanocrystals in the drug formulation is increasing due to the large number of
poorly water-soluble drug compounds synthetized and due to the advantages brought by the …

In pharmaceutical research and development, various new chemical entities (NCE) are
found to be poorly water-soluble. Therefore, solubility enhancement, a key factor for higher …

During the last few decades the nanomedicine sector has emerged as a feasible and
effective solution to the problems faced by the high percentage of poorly water-soluble …

The solubility and bioavailability of pharmaceutical compounds are increased via size
reduction. The conventional size reduction methods have some disadvantages. The …

A method of rapid expansion of supercritical solutions with solid cosolvent (RESS-SC) was
applied, for the first time, to precipitate nanoparticles of Letrozole (LTZ). Solubility of LTZ, as …