Parkinson's disease is one of the most common neurodegenerative diseases affecting the
ageing population, with a prevalence that has doubled over the last 30 years. As the …

Brown and beige adipocytes produce heat and control systemic energy via non-shivering
thermogenesis. Historically, thermogenesis in brown and beige adipocytes was thought to …

Background and Purpose High levels of Ca2+ in the endoplasmic reticulum (ER),
established by the sarco/endoplasmic reticulum Ca2+ ATPase (SERCA), are required for …

Skeletal muscle abnormalities and atrophy during unloading are accompanied by the
accumulation of excess calcium in the sarcoplasm. We hypothesized that calcium …

Electrical pulse stimulation (EPS) has proven to be a useful tool to interrogate cell-specific
responses to muscle contraction. In the present study, we aimed to uncover networks of …

Wolfram syndrome is a rare genetic disease caused by mutations in the WFS1 or CISD2
gene. A primary defect in Wolfram syndrome involves poor ER Ca2+ handling, but how this …

Excessive organophosphate flame retardant (OPFR) use in consumer products has been
reported to increase human disease susceptibility. However, the adverse effects of tris (2 …

Background: Sarco/endoplasmic reticulum Ca2+-ATPase2 (SERCA2) is impaired in various
organs in animal models of diabetes. The purpose of this study was to test the effects of an …

Mast cells are granulocytic immune sentinels present in vascularized tissues that drive
chronic inflammatory mechanisms characteristic of allergic pathologies. IgE‐mediated mast …

Metabolic dysfunction-associated steatotic liver disease is the most common form of liver
disease and poses significant health risks to patients who progress to metabolic dysfunction …