Cyclic AMP (cAMP) plays a key regulatory role in most types of cells; however, the pathways
controlled by cAMP may present important differences between organisms and between …

Mycobacterium tuberculosis (Mtb) replicates within host macrophages by adapting to the
stressful and nutritionally constrained environments in these cells. Exploiting these …

While nucleic acid-targeting effectors are known to be central to biological conflicts and anti-
selfish element immunity, recent findings have revealed immune effectors that target their …

Cyclic AMP synthesized by Mycobacterium tuberculosis has been shown to play a role in
pathogenesis. However, the high levels of intracellular cAMP found in both pathogenic and …

An enhanced understanding of the metal ion binding and active site structural features of
phosphoesterases such as the glycerophosphodiesterase from Enterobacter aerogenes …

Eukaryotic cells produce a family of diverse inositol polyphosphates (IPs) containing
pyrophosphate bonds. Inositol pyrophosphates have been linked to a wide range of cellular …

Cyclic AMP (cAMP) is an important second messenger signaling molecule that controls a
wide variety of eukaryotic and prokaryotic responses to extracellular cues. For cAMP …

Summary cAMP is an ancient second messenger, and is used by many organisms to
regulate a wide range of cellular functions. Mycobacterium tuberculosis complex bacteria …

Bacillus subtilis mutants lacking ymdB are unable to form biofilms, exhibit a strong
overexpression of the flagellin gene hag, and are deficient in SlrR, a SinR antagonist. Here …

Fe and Zn ions are essential enzymatic cofactors across all domains of life. Fe is an electron
donor/acceptor in redox enzymes, while Zn is typically a structural element or catalytic …