Biological roles of cAMP: variations on a theme in the different kingdoms of life
JM Gancedo - Biological Reviews, 2013 - Wiley Online Library
Cyclic AMP (cAMP) plays a key regulatory role in most types of cells; however, the pathways
controlled by cAMP may present important differences between organisms and between …
controlled by cAMP may present important differences between organisms and between …
Exploiting cAMP signaling in Mycobacterium tuberculosis for drug discovery
D Kathayat, BC VanderVen - Trends in Microbiology, 2024 - cell.com
Mycobacterium tuberculosis (Mtb) replicates within host macrophages by adapting to the
stressful and nutritionally constrained environments in these cells. Exploiting these …
stressful and nutritionally constrained environments in these cells. Exploiting these …
Functionally comparable but evolutionarily distinct nucleotide-targeting effectors help identify conserved paradigms across diverse immune systems
While nucleic acid-targeting effectors are known to be central to biological conflicts and anti-
selfish element immunity, recent findings have revealed immune effectors that target their …
selfish element immunity, recent findings have revealed immune effectors that target their …
cAMP-regulated protein lysine acetylases in mycobacteria
S Nambi, N Basu, SS Visweswariah - Journal of Biological Chemistry, 2010 - ASBMB
Cyclic AMP synthesized by Mycobacterium tuberculosis has been shown to play a role in
pathogenesis. However, the high levels of intracellular cAMP found in both pathogenic and …
pathogenesis. However, the high levels of intracellular cAMP found in both pathogenic and …
Spectroscopic and mechanistic studies of dinuclear metallohydrolases and their biomimetic complexes
An enhanced understanding of the metal ion binding and active site structural features of
phosphoesterases such as the glycerophosphodiesterase from Enterobacter aerogenes …
phosphoesterases such as the glycerophosphodiesterase from Enterobacter aerogenes …
Inositol hexakisphosphate kinase products contain diphosphate and triphosphate groups
P Draškovič, A Saiardi, R Bhandari, A Burton, G Ilc… - Chemistry & biology, 2008 - cell.com
Eukaryotic cells produce a family of diverse inositol polyphosphates (IPs) containing
pyrophosphate bonds. Inositol pyrophosphates have been linked to a wide range of cellular …
pyrophosphate bonds. Inositol pyrophosphates have been linked to a wide range of cellular …
In Vitro and In Vivo Characterization of the Pseudomonas aeruginosa Cyclic AMP (cAMP) Phosphodiesterase CpdA, Required for cAMP Homeostasis and …
EL Fuchs, ED Brutinel, ER Klem, AR Fehr… - Journal of …, 2010 - Am Soc Microbiol
Cyclic AMP (cAMP) is an important second messenger signaling molecule that controls a
wide variety of eukaryotic and prokaryotic responses to extracellular cues. For cAMP …
wide variety of eukaryotic and prokaryotic responses to extracellular cues. For cAMP …
Cyclic AMP signalling in mycobacteria: redirecting the conversation with a common currency
G Bai, GS Knapp, KA McDonough - Cellular microbiology, 2011 - Wiley Online Library
Summary cAMP is an ancient second messenger, and is used by many organisms to
regulate a wide range of cellular functions. Mycobacterium tuberculosis complex bacteria …
regulate a wide range of cellular functions. Mycobacterium tuberculosis complex bacteria …
The YmdB phosphodiesterase is a global regulator of late adaptive responses in Bacillus subtilis
C Diethmaier, JA Newman, ÁT Kovács… - Journal of …, 2014 - Am Soc Microbiol
Bacillus subtilis mutants lacking ymdB are unable to form biofilms, exhibit a strong
overexpression of the flagellin gene hag, and are deficient in SlrR, a SinR antagonist. Here …
overexpression of the flagellin gene hag, and are deficient in SlrR, a SinR antagonist. Here …
The Fe and Zn cofactor dilemma
J Chen, LA Calderone, L Pan, T Quist… - Biochimica et Biophysica …, 2023 - Elsevier
Fe and Zn ions are essential enzymatic cofactors across all domains of life. Fe is an electron
donor/acceptor in redox enzymes, while Zn is typically a structural element or catalytic …
donor/acceptor in redox enzymes, while Zn is typically a structural element or catalytic …