Quinones can in principle be viewed as a double-edged sword in the treatment of
neurodegenerative diseases, since they are often cytoprotective but can also be cytotoxic …

Many members of the heat shock protein family act in unison to refold or degrade misfolded
proteins. Some heat shock proteins also directly interfere with apoptosis. These homeostatic …

A number of acute and chronic neurodegenerative disorders are caused due to misfolding
and aggregation of many intra-and extracellular proteins. Protein misfolding and …

Manganese (Mn) is an abundant, naturally occurring element in the Earth's crust. It is most
frequently found in the form of oxides, carbonates, and silicates. 1 It is also one out of seven …

Cell therapy has attracted considerable interest as a promising therapeutic alternative for
patients with Parkinson's disease (PD). Clinical studies have shown that grafted fetal neural …

Background: The 90-kDa heat-shock proteins (Hsp90) have rapidly evolved into promising
therapeutic targets for the treatment of several diseases, including cancer and …

The success of early drug-discovery programs depends on the adequate combination of
complementary and orthogonal technologies allowing hit/lead compounds to be optimized …

Mutations in leucine-rich repeat kinase 2 gene (PARK8/LRRK2) encoding the protein Lrrk2
are causative of inherited and sporadic Parkinson's disease (PD) with phenotypic …

Leucine‐rich repeat kinase 2 (LRRK2) is a large, complex, multidomain protein containing
kinase and GTPase enzymatic activities and multiple protein–protein interaction domains …

A potential cause of neurodegenerative diseases, including Parkinson's disease (PD), is
protein misfolding and aggregation that in turn leads to neurotoxicity. Targeting Hsp90 is an …