Circulating tumor cells (CTCs) are the seeds of distant metastasis, and the number of CTCs
detected in the blood of cancer patients is associated with a worse prognosis. CTCs face …

Tumorigenesis is a complex process involving dynamic interactions between malignant cells
and their surrounding stroma, including both the cellular and acellular components. Within …

Background Besides featured glucose consumption, recent studies reveal that cancer cells
might prefer “addicting” specific energy substrates from the tumor microenvironment (TME); …

A biodegradable drug delivery system (DDS) is one the most promising therapeutic
strategies for cancer therapy. Here, we propose a unique concept of light activation of black …

Chemoresistance remains the major obstacle to achieve optimal prognosis in gastric cancer
patients, and the underlying molecular mechanisms of cancer-associated fibroblasts (CAFs) …

Cancer is a major stress for public well‐being and is the most dreadful disease. The models
used in the discovery of cancer treatment are continuously changing and extending toward …

Zebrafish are teleosts (bony fish) that share with mammals a common ancestor belonging to
the phylum Osteichthyes, from which their endoskeletal systems have been inherited …

Development of novel and effective therapeutics for treating various cancers is probably the
most congested and challenging enterprise of pharmaceutical companies. Diverse drugs …

Podoplanin (PDPN) is a transmembrane receptor glycoprotein that is upregulated on
transformed cells, cancer associated fibroblasts and inflammatory macrophages that …

As a promising in vivo tool for cancer research, zebrafish have been widely applied in
various tumor studies. The zebrafish xenograft model is a low-cost, high-throughput tool for …