Stimulator of interferons genes (STING), which is crucial for the secretion of type I interferons
and proinflammatory cytokines in response to cytosolic nucleic acids, plays a key role in the …

Studying the complex molecular mechanisms involved in traumatic brain injury (TBI) is
crucial for developing new therapies for TBI. Current treatments for TBI are primarily focused …

Hydroethidine (HE; or dihydroethidium) is the most popular fluorogenic probe used for
detecting intracellular superoxide radical anion. The reaction between superoxide and HE …

Abstract APE1/Ref-1 (APE1), the mammalian ortholog of Escherichia coli Xth, and a
multifunctional protein possessing both DNA repair and transcriptional regulatory activities …

Stroke is associated with a limited degree of functional recovery. Imaging studies in humans
have shown that reorganization in periinfarct and connected cortical areas most closely …

After a severe episode of ischemia, traumatic brain injury (TBI) or epilepsy, it is typical to find
necrotic cell death within the injury core. In addition, a substantial number of neurons in …

Oxidative stress has been identified as an important contributor to neurodegeneration
associated with acute CNS injuries and diseases such as spinal cord injury (SCI), traumatic …

Object. Previous studies undertaken by the authors have indicated that iron accumulation
and oxidative stress in the brain contribute to secondary brain damage after intracerebral …

The mammalian AP-endonuclease (APE1/Ref-1) plays a central role in the repair of oxidized
and alkylated bases in mammalian genomes via the base excision repair (BER) pathway …

The older neurocentric view of the central nervous system (CNS) has changed radically with
the growing understanding of the many essential functions of astrocytes. Advances in our …