Cells produce multiple mRNAs through alternative splicing, which ensures proteome
diversity. Because most human genes undergo alternative splicing, key components of …

Signal transducer and activator of transcription 3 (STAT3) is a member of the Janus kinase
(JAK)-STAT pathway, which is one of the key pathways contributing to cancer. STAT3 …

Natural killer (NK) cells are derived from hematopoietic stem cells. They belong to the innate
lymphoid cell family, which is an important part of innate immunity. This family plays a role in …

CD4 T helper (Th) cell subsets, including Th1, Th2 and Th17 cells, and their innate
counterparts innate lymphoid cell (ILC) subsets consisting of ILC1s, ILC2s and ILC3s …

Objective. The aim of this research was to create a new genetic signature of immune
checkpoint‐associated genes as a prognostic method for pediatric acute myeloid leukemia …

Natural killer (NK) cells are critical innate lymphocytes that can directly kill target cells
without prior immunization. NK cell activation is controlled by the balance of multiple …

Oncogenic kinases contribute to immunosuppression and modulate the tumor
microenvironment in solid tumors. Increasing evidence supports the fundamental role of …

Background Signal transducer and activator of transcription (STAT) is a unique protein
family that binds to DNA and plays a vital role in regulating major physiological cellular …

T‐bet and Eomes are two related transcription factors (TFs) that regulate the differentiation of
cytotoxic lymphocytes such as Natural Killer (NK) cells and CD8 T cells. Recent genome …

Cytokines are the crucial signaling proteins that mediate the crosstalks between the cells of
tumor microenvironment (TME). Interferon-1 (IFN-1) are the important cytokines that are …