[HTML][HTML] Gene body methylation in cancer: molecular mechanisms and clinical applications
Q Wang, F Xiong, G Wu, W Liu, J Chen, B Wang… - Clinical …, 2022 - Springer
DNA methylation is an important epigenetic mechanism that regulates gene expression. To
date, most DNA methylation studies have focussed on CpG islands in the gene promoter …
date, most DNA methylation studies have focussed on CpG islands in the gene promoter …
One-carbon metabolism: linking nutritional biochemistry to epigenetic programming of long-term development
CE Clare, AH Brassington, WY Kwong… - Annual review of …, 2019 - annualreviews.org
One-carbon (1C) metabolism comprises a series of interlinking metabolic pathways that
include the methionine and folate cycles that are central to cellular function, providing 1C …
include the methionine and folate cycles that are central to cellular function, providing 1C …
RNA m6A regulates transcription via DNA demethylation and chromatin accessibility
Transcriptional regulation, which integrates chromatin accessibility, transcription factors and
epigenetic modifications, is crucial for establishing and maintaining cell identity. The …
epigenetic modifications, is crucial for establishing and maintaining cell identity. The …
[HTML][HTML] Hotspots of human mutation
Mutation of the human genome results in three classes of genomic variation: single
nucleotide variants; short insertions or deletions; and large structural variants (SVs). Some …
nucleotide variants; short insertions or deletions; and large structural variants (SVs). Some …
[HTML][HTML] Biology and pathogenesis of human osteosarcoma
JWV de Azevedo, TAAM Fernandes… - Oncology …, 2020 - spandidos-publications.com
Osteosarcoma (OS) is a bone tumor of mesenchymal origin, most frequently occurring
during the rapid growth phase of long bones, and usually located in the epiphyseal growth …
during the rapid growth phase of long bones, and usually located in the epiphyseal growth …
[HTML][HTML] Alternative promoters in CpG depleted regions are prevalently associated with epigenetic misregulation of liver cancer transcriptomes
C Nepal, JB Andersen - Nature Communications, 2023 - nature.com
Transcriptional regulation is commonly governed by alternative promoters. However, the
regulatory architecture in alternative and reference promoters, and how they differ, remains …
regulatory architecture in alternative and reference promoters, and how they differ, remains …
[HTML][HTML] Intragenic CpG islands and their impact on gene regulation
JA Cain, B Montibus, RJ Oakey - Frontiers in Cell and Developmental …, 2022 - frontiersin.org
The mammalian genome is depleted in CG dinucleotides, except at protected regions where
they cluster as CpG islands (CGIs). CGIs are gene regulatory hubs and serve as …
they cluster as CpG islands (CGIs). CGIs are gene regulatory hubs and serve as …
[HTML][HTML] DNMT3B functions: novel insights from human disease
M Gagliardi, M Strazzullo… - Frontiers in cell and …, 2018 - frontiersin.org
DNA methylation plays important roles in gene expression regulation and chromatin
structure. Its proper establishment and maintenance are essential for mammalian …
structure. Its proper establishment and maintenance are essential for mammalian …
[HTML][HTML] PERSIST platform provides programmable RNA regulation using CRISPR endoRNases
B DiAndreth, N Wauford, E Hu, S Palacios… - Nature …, 2022 - nature.com
Regulated transgene expression is an integral component of gene therapies, cell therapies
and biomanufacturing. However, transcription factor-based regulation, upon which most …
and biomanufacturing. However, transcription factor-based regulation, upon which most …